Regulation of heterogeneous cancer-associated fibroblasts: the molecular pathology of activated signaling pathways

Abstract Accumulating evidence indicates that intratumoral heterogeneity contributes to the development of resistance to anticancer therapeutics. Fibroblasts, which are components of the paraneoplastic stroma, play a crucial role in the wound-healing process. Activated fibroblasts accumulate in the...

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Bibliographic Details
Main Author: Go J. Yoshida
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13046-020-01611-0