OVOL2-Mediated ZEB1 Downregulation May Prevent Promotion of Actinic Keratosis to Cutaneous Squamous Cell Carcinoma

OVOL2-Mediated ZEB1 Downregulation May Prevent Promotion of Actinic Keratosis to Cutaneous Squamous Cell Carcinoma

Progression of actinic keratosis (AK) to cutaneous squamous cell carcinoma (cSCC) is rare. Most cases of AK remain as intraepidermal lesions, owing to the suppression of the epithelial-to-mesenchymal transition (EMT). Ovo-like transcriptional repressor 1 (OVOL1) and ovo-like zinc finger 2 (OVOL2) ar...

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Bibliographic Details
Main Authors: Maho Murata, Takamichi Ito, Yuka Tanaka, Kazuhiko Yamamura, Kazuhisa Furue, Masutaka Furue
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Journal of Clinical Medicine
Subjects:
actinic keratosis
cutaneous squamous cell carcinoma
emt
ovol2
zeb1
ovol1
twist1
snail
vimentin
e-cadherin
Online Access:https://www.mdpi.com/2077-0383/9/3/618

Internet

https://www.mdpi.com/2077-0383/9/3/618

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