Constraining PERMANOVA and LDM to within-set comparisons by projection improves the efficiency of analyses of matched sets of microbiome data

Constraining PERMANOVA and LDM to within-set comparisons by projection improves the efficiency of analyses of matched sets of microbiome data

Abstract Background Matched-set data arise frequently in microbiome studies. For example, we may collect pre- and post-treatment samples from a set of individuals, or use important confounding variables to match data from case participants to one or more control participants. Thus, there is a need f...

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Bibliographic Details
Main Authors: Zhengyi Zhu, Glen A. Satten, Caroline Mitchell, Yi-Juan Hu
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Microbiome
Subjects:
Microbiome association test
Differentially abundant
Clustered data
Paired data
Unbalanced data
Online Access:https://doi.org/10.1186/s40168-021-01034-9

Internet

https://doi.org/10.1186/s40168-021-01034-9

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