SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements.
Mms21, a subunit of the Smc5/6 complex, possesses an E3 ligase activity for the Small Ubiquitin-like MOdifier (SUMO). Here we show that the mms21-CH mutation, which inactivates Mms21 ligase activity, causes increased accumulation of gross chromosomal rearrangements (GCRs) selected in the dGCR assay....
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-03-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC5860785?pdf=render |