SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements.

SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements.

Mms21, a subunit of the Smc5/6 complex, possesses an E3 ligase activity for the Small Ubiquitin-like MOdifier (SUMO). Here we show that the mms21-CH mutation, which inactivates Mms21 ligase activity, causes increased accumulation of gross chromosomal rearrangements (GCRs) selected in the dGCR assay....

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Bibliographic Details
Main Authors: Jason Liang, Bin-Zhong Li, Alexander P Tan, Richard D Kolodner, Christopher D Putnam, Huilin Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5860785?pdf=render

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http://europepmc.org/articles/PMC5860785?pdf=render

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