Advance in the Treatment of Pediatric Leukemia

• Format: eBook
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Chemistry; Research & information: general; 5-azacitidine; ABCC4; acute lymphoblastic leukemia; acute myeloid leukemia; acute pancreatitis; ADC; advances; ALL; allogeneic stem cell transplantation; alternative donors; AML; antibody; antibody-drug conjugate; B-ALL; BCL11B; BCP-ALL; bispecific T-cell engager (BiTE); CD19; CFTR; childhood acute lymphoblastic leukemia; children; chronic myeloid leukemia; CML; conditioning regimen; COVID-19; diagnosis; DUX4; evolution of CAR T cells; Fc-engineering; FDA-approved CAR products; future directions of CAR T cell therapy; genome; hematopoietic stem cell transplantation; IKZF1; immunizations; immunotherapy; juvenile myelomonocytic leukemia; L-asparaginase; leukemia; limitations and complications of CAR T cell therapy; low-risk ALL; lymphoblastic leukemia; minimal residual disease; myelodysplastic/myeloproliferative disorders; n/a; NOTCH1; NUTM1; other extramedullary relapse; PAX5; pediatric; pediatric leukemia; Ph-like; polymorphism; prognosis; RAS signaling; risk-stratified treatment; SNV; T-ALL; targeted therapy; TcR versus CAR; TRAIL; transcriptome; treatment; treatment related toxicity; tyrosine kinase inhibitor; xenograft; ZNF384
• Online Access: Open Access: DOAB: description of the publication; Open Access: DOAB, download the publication
• Physical Description: 1 online resource (300 p.)
• ISBN: 9783036541679; 9783036541686; books978-3-0365-4168-6
• Access: Open Access

The book gives an overview on the progress that has been made in the treatment of acute lymphoblastic leukemia (ALL), of acute and chronic myeloid leukemia (AML, CML) and of juvenile myelomonocytic leukemia (JMML). Leukemia is the most common malignant disease in children, and 80% of patients are diagnosed with ALL and 15-20% with AML, whereas CML and JMML are rather rare. Although ALL was considered an incurable disease until the early 1960s, with the availability of cytotoxic drugs and the start of clinical multicenter studies, ALL has become an almost curable disease with a survival rate exceeding 90 % in high-income countries. These impressive results have mainly been achieved by a deeper understanding of the genomic landscape of the disease and the introduction of risk stratifications based on genetic features and response to chemotherapy as determined by the presence or absence of minimal residual disease (MRD). Immunotherapies including bispecific T-cell Engagers (BiTEs), Chimeric Antigen Receptor (CAR) T cells, monoclonal antibodies and improvements in the outcome of allogeneic stem cell transplantation (HSCT) have shown impressive results in chemorefractory or relapsed patients, and it is anticipated that the cure rate can be further increased. For countries with less resources, therapies have to be adapted to increase survival as well. This book also updates on the progress made in the treatment of AML. As in ALL, risk classification based on genetic factors and response to chemotherapy is most important for therapy guidance. The book also provides updates and guidance for the treatment of CML and JMML.