Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics

Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics

The sense of hearing is vulnerable to environmental challenges, such as exposure to noise. More than 1.5 billion people experience some decline in hearing ability during their lifetime, of whom at least 430 million will be affected by disabling hearing loss. If not identified and addressed in a time...

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Bibliographic Details
Format: eBook
Language:English
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
Subjects:
Medicine and Nursing
adenosine A1 receptor
adjunctive therapy
age-related hearing loss
aging
astrocytes
auditory brainstem
brain-derived neurotrophic factor
CCG-4986
chronic oral treatment
circadian dysregulation
clock genes
cochlear nucleus
cochlear rescue
d-galactose
deafness
development
gap junctions
hearing loss
hearing protection
high-fat diet
hyperbaric oxygenation
hypoxic
inferior colliculus
inner ear
intratympanic drug delivery
KCNQ4 activator
lateral superior olive
microRNAs
mitochondria dysfunction
mouse model
n/a
neuroplasticity
noise-induced cochlear injury
noise-induced hearing loss
nonsyndromic hearing loss
otoferlin
otoprotection
potassium
potassium voltage-gated channel subfamily q member 4
reactive oxygen species
regulator of G protein signalling 4
selegiline
sensorineural hearing loss
sensory hair cells
spontaneous activity
synaptic ribbons
TrkB
voltage-activated calcium channel 1.3
zebrafish
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