Genetic and Epigenetic Regulations of Tumor Progression and Metastasis
Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therap...
| Format: | eBook |
|---|---|
| Language: | English |
| Published: |
Basel
MDPI - Multidisciplinary Digital Publishing Institute
2023
|
| Subjects: | |
| Online Access: | Open Access: DOAB: description of the publication Open Access: DOAB, download the publication |
| LEADER | 04047namaa2201093uu 4500 | ||
|---|---|---|---|
| 001 | doab100008 | ||
| 003 | oapen | ||
| 005 | 20230511 | ||
| 006 | m o d | ||
| 007 | cr|mn|---annan | ||
| 008 | 230511s2023 xx |||||o ||| 0|eng d | ||
| 020 | |a 9783036571843 | ||
| 020 | |a 9783036571850 | ||
| 020 | |a books978-3-0365-7184-3 | ||
| 024 | 7 | |a 10.3390/books978-3-0365-7184-3 |2 doi | |
| 040 | |a oapen |c oapen | ||
| 041 | 0 | |a eng | |
| 042 | |a dc | ||
| 072 | 7 | |a M |2 bicssc | |
| 072 | 7 | |a MJCL |2 bicssc | |
| 720 | 1 | |a Smolkova, Bozena |4 edt | |
| 720 | 1 | |a Earl, Julie |4 edt | |
| 720 | 1 | |a Earl, Julie |4 oth | |
| 720 | 1 | |a Kataki, Agapi |4 edt | |
| 720 | 1 | |a Kataki, Agapi |4 oth | |
| 720 | 1 | |a Smolkova, Bozena |4 oth | |
| 245 | 0 | 0 | |a Genetic and Epigenetic Regulations of Tumor Progression and Metastasis |
| 260 | |a Basel |b MDPI - Multidisciplinary Digital Publishing Institute |c 2023 | ||
| 300 | |a 1 online resource (208 p.) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 506 | 0 | |a Open Access |f Unrestricted online access |2 star | |
| 520 | |a Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therapies that are frequently located in genes that regulate DNA methylation and chromatin modifications. Recent studies have shown that distinct subgroups of poor-prognosis tumors lack genetic alterations but are epigenetically regulated, pointing to the critical role of epigenetic modifications in cancer progression. This Special Issue provides novel insights into the mechanisms underlying processes associated with cancer cell plasticity and the development of metastatic disease. | ||
| 540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |u https://creativecommons.org/licenses/by/4.0/ | ||
| 546 | |a English | ||
| 650 | 7 | |a Medicine and Nursing |2 bicssc | |
| 650 | 7 | |a Oncology |2 bicssc | |
| 653 | |a 5-azacytidine | ||
| 653 | |a adaptive responses | ||
| 653 | |a adipose tissue | ||
| 653 | |a angiogenesis | ||
| 653 | |a autophagy | ||
| 653 | |a brain metastasis | ||
| 653 | |a breast cancer | ||
| 653 | |a cancer proliferation | ||
| 653 | |a cancer therapy | ||
| 653 | |a CDH1 gene | ||
| 653 | |a CDKN2A | ||
| 653 | |a cell adhesion | ||
| 653 | |a colorectal cancer | ||
| 653 | |a CYSLTR1 | ||
| 653 | |a CYSLTR2 | ||
| 653 | |a diagnostic biomarker | ||
| 653 | |a DNA methylation | ||
| 653 | |a E-cadherin | ||
| 653 | |a EMT | ||
| 653 | |a EMT genes | ||
| 653 | |a endothelial cells | ||
| 653 | |a engineered exosomes | ||
| 653 | |a epithelial-to-mesenchymal transition | ||
| 653 | |a epithelial-to-mesenchymal transition (EMT) | ||
| 653 | |a gene transcription | ||
| 653 | |a hepatocellular carcinoma | ||
| 653 | |a HTR2B | ||
| 653 | |a hypoxia | ||
| 653 | |a inflammation | ||
| 653 | |a intra-tumor heterogeneity | ||
| 653 | |a invasive ductal breast cancer | ||
| 653 | |a lung adenocarcinoma | ||
| 653 | |a lung cancer | ||
| 653 | |a metastasis | ||
| 653 | |a metastatic cascade | ||
| 653 | |a methylation | ||
| 653 | |a miRNA and mRNA expression | ||
| 653 | |a mutational profile | ||
| 653 | |a n/a | ||
| 653 | |a omics data analysis | ||
| 653 | |a p16 | ||
| 653 | |a partial-EMT (p-EMT) | ||
| 653 | |a PDAC | ||
| 653 | |a pericytes | ||
| 653 | |a prognosis | ||
| 653 | |a promoter | ||
| 653 | |a prostate cancer | ||
| 653 | |a STAT proteins | ||
| 653 | |a tumor microenvironment | ||
| 653 | |a tumor mutational burden | ||
| 653 | |a uveal melanoma | ||
| 653 | |a waterpipe smoke | ||
| 653 | |a Zeb1 | ||
| 793 | 0 | |a DOAB Library. | |
| 856 | 4 | 0 | |u https://directory.doabooks.org/handle/20.500.12854/100008 |7 0 |z Open Access: DOAB: description of the publication |
| 856 | 4 | 0 | |u https://mdpi.com/books/pdfview/book/7101 |7 0 |z Open Access: DOAB, download the publication |