Data from molecular dynamics simulations in support of the role of human CES1 in the hydrolysis of Amplex Red

by Giulio Vistoli, Achim Treumann, Thomas von Zglinicki, Satomi Miwa
Published 2016-03-01

Senolytics and senostatics as adjuvant tumour therapy

by Susan Short, Edward Fielder, Satomi Miwa, Thomas von Zglinicki
Published 2019-03-01

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

by Viktor I. Korolchuk, Satomi Miwa, Bernadette Carroll, Thomas von Zglinicki
Published 2017-07-01

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations.

by Conor Lawless, Diana Jurk, Colin S Gillespie, Daryl Shanley, Gabriele Saretzki, Thomas von Zglinicki, João F Passos
Published 2012-01-01

Childhood growth, IQ and education as predictors of white blood cell telomere length at age 49-51 years: the Newcastle Thousand Families Study.

by Mark S Pearce, Kay D Mann, Carmen Martin-Ruiz, Louise Parker, Martin White, Thomas von Zglinicki, Jean Adams
Published 2012-01-01

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

by Yasumichi Arai, Carmen M. Martin-Ruiz, Michiyo Takayama, Yukiko Abe, Toru Takebayashi, Shigeo Koyasu, Makoto Suematsu, Nobuyoshi Hirose, Thomas von Zglinicki
Published 2015-10-01

Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions.

by Piero Dalle Pezze, Glyn Nelson, Elsje G Otten, Viktor I Korolchuk, Thomas B L Kirkwood, Thomas von Zglinicki, Daryl P Shanley
Published 2014-08-01

The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol

by Martin-Ruiz Carmen, James Oliver, Jagger Carol, Eccles Martin, Bond John, Barrass Karen, Collerton Joanna, Robinson Louise, von Zglinicki Thomas, Kirkwood Tom
Published 2007-06-01

High-throughput 13-parameter immunophenotyping identifies shifts in the circulating T-cell compartment following reperfusion in patients with acute myocardial infarction.

by Jedrzej Hoffmann, Karel Fiser, Jolanta Weaver, Ian Dimmick, Monika Loeher, Hanspeter Pircher, Carmen Martin-Ruiz, Murugapathy Veerasamy, Bernard Keavney, Thomas von Zglinicki, Ioakim Spyridopoulos
Published 2012-01-01

CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

by Carmen Martin-Ruiz, Jedrzej Hoffmann, Evgeniya Shmeleva, Thomas von Zglinicki, Gavin Richardson, Lilia Draganova, Rachael Redgrave, Joanna Collerton, Helen Arthur, Bernard Keavney, Ioakim Spyridopoulos
Published 2020-01-01

Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs

by von Zglinicki Thomas, Eccles Martin P, Robinson Louise A, Kingston Andrew, Davies Karen, Collerton Joanna C, Jagger Carol, Martin-Ruiz Carmen, James Oliver FW, Kirkwood Tom BL, Bond John
Published 2011-05-01

Reactive oxygen species production and mitochondrial dysfunction in white blood cells are not valid biomarkers of ageing in the very old.

by Laura Wiley, Deepthi Ashok, Carmen Martin-Ruiz, Duncan C S Talbot, Joanna Collerton, Andrew Kingston, Karen Davies, Patrick F Chinnery, Michael Catt, Carol Jagger, Thomas B L Kirkwood, Thomas von Zglinicki
Published 2014-01-01

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.

by João F Passos, Gabriele Saretzki, Shaheda Ahmed, Glyn Nelson, Torsten Richter, Heiko Peters, Ilka Wappler, Matthew J Birket, Graham Harold, Karin Schaeuble, Mark A Birch-Machin, Thomas B L Kirkwood, Thomas von Zglinicki
Published 2007-05-01

The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice

by Sabine A. S. Langie, Kerry M. Cameron, Gabriella Ficz, David Oxley, Bartłomiej Tomaszewski, Joanna P. Gorniak, Lou M. Maas, Roger W. L. Godschalk, Frederik J. van Schooten, Wolf Reik, Thomas von Zglinicki, John C. Mathers
Published 2017-02-01

Telomere length and physical performance at older ages: an individual participant meta-analysis.

by Michael P Gardner, Carmen Martin-Ruiz, Rachel Cooper, Rebecca Hardy, Avan Aihie Sayer, Cyrus Cooper, Ian J Deary, John Gallacher, Sarah E Harris, Paul G Shiels, John M Starr, Diana Kuh, Thomas von Zglinicki, Yoav Ben-Shlomo, Halcyon study team
Published 2013-01-01

Cellular senescence drives age-dependent hepatic steatosis

by Mikolaj Ogrodnik, Satomi Miwa, Tamar Tchkonia, Dina Tiniakos, Caroline L. Wilson, Albert Lahat, Christoper P. Day, Alastair Burt, Allyson Palmer, Quentin M. Anstee, Sushma Nagaraja Grellscheid, Jan H J. Hoeijmakers, Sander Barnhoorn, Derek A. Mann, Thomas G. Bird, Wilbert P. Vermeij, James L. Kirkland, João F. Passos, Thomas von Zglinicki, Diana Jurk
Published 2017-06-01

Smoking does not accelerate leucocyte telomere attrition: a meta-analysis of 18 longitudinal cohorts

by Melissa Bateson, Abraham Aviv, Laila Bendix, Athanase Benetos, Yoav Ben-Shlomo, Stig E. Bojesen, Cyrus Cooper, Rachel Cooper, Ian J. Deary, Sara Hägg, Sarah E. Harris, Jeremy D. Kark, Florian Kronenberg, Diana Kuh, Carlos Labat, Carmen M. Martin-Ruiz, Craig Meyer, Børge G. Nordestgaard, Brenda W. J. H. Penninx, Gillian V. Pepper, Dóra Révész, M. Abdullah Said, John M. Starr, Holly Syddall, William Murray Thomson, Pim van der Harst, Mary Whooley, Thomas von Zglinicki, Peter Willeit, Yiqiang Zhan, Daniel Nettle
Published 2019-06-01