Site-Specific Modification Using the 2′-Methoxyethyl Group Improves the Specificity and Activity of siRNAs

by Xinyun Song, Xiaoxia Wang, Yuan Ma, Zicai Liang, Zhenjun Yang, Huiqing Cao
Published 2017-12-01

Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.

by Weiyan Huang, Mei Zhao, Na Wei, Xiaoxia Wang, Huqing Cao, Quan Du, Zicai Liang
Published 2014-01-01

siRNA has greatly elevated mismatch tolerance at 3'-UTR sites.

by Na Wei, Lei Zhang, Huang Huang, Yue Chen, Jie Zheng, Xiao Zhou, Fan Yi, Quan Du, Zicai Liang
Published 2012-01-01

Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle

by Tongren Yang, Chunhui Li, Xiaoxia Wang, Deyao Zhao, Mengjie Zhang, Huiqing Cao, Zicai Liang, Haihua Xiao, Xing-Jie Liang, Yuhua Weng, Yuanyu Huang
Published 2020-12-01

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

by Defang Li, Jin Liu, Baosheng Guo, Chao Liang, Lei Dang, Cheng Lu, Xiaojuan He, Hilda Yeuk-Siu Cheung, Liang Xu, Changwei Lu, Bing He, Biao Liu, Atik Badshah Shaikh, Fangfei Li, Luyao Wang, Zhijun Yang, Doris Wai-Ting Au, Songlin Peng, Zongkang Zhang, Bao-Ting Zhang, Xiaohua Pan, Airong Qian, Peng Shang, Lianbo Xiao, Baohong Jiang, Chris Kong-Chu Wong, Jiake Xu, Zhaoxiang Bian, Zicai Liang, De-an Guo, Hailong Zhu, Weihong Tan, Aiping Lu, Ge Zhang
Published 2016-03-01