A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry

by J. Maximilian Fels, Jennifer S. Spence, Robert H. Bortz, Zachary A. Bornholdt, Kartik Chandran
Published 2019-07-01

Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop

by Charles D. Murin, Jessica F. Bruhn, Zachary A. Bornholdt, Jeffrey Copps, Robyn Stanfield, Andrew B. Ward
Published 2018-09-01

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies

by Zachary A. Bornholdt, Esther Ndungo, Marnie L. Fusco, Shridhar Bale, Andrew I. Flyak, James E. Crowe, Kartik Chandran, Erica Ollmann Saphire
Published 2016-02-01

Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers

by William Wan, Mairi Clarke, Michael J Norris, Larissa Kolesnikova, Alexander Koehler, Zachary A Bornholdt, Stephan Becker, Erica Ollmann Saphire, John AG Briggs
Published 2020-10-01

The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold.

by Adrianna P P Zhang, Zachary A Bornholdt, Tong Liu, Dafna M Abelson, David E Lee, Sheng Li, Virgil L Woods, Erica Ollmann Saphire
Published 2012-02-01

Correction: The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold.

by Adrianna P. P. Zhang, Zachary A. Bornholdt, Tong Liu, Dafna M. Abelson, David E. Lee, Sheng Li, Virgil L. Woods, Erica Ollmann Saphire
Published 2013-12-01

Prior vaccination with rVSV-ZEBOV does not interfere with but improves efficacy of postexposure antibody treatment

by Robert W. Cross, Zachary A. Bornholdt, Abhishek N. Prasad, Joan B. Geisbert, Viktoriya Borisevich, Krystle N. Agans, Daniel J. Deer, Kevin Melody, Karla A. Fenton, Heinz Feldmann, Armand Sprecher, Larry Zeitlin, Thomas W. Geisbert
Published 2020-07-01

Neutralizing Antibodies against Crimean–Congo Hemorrhagic Fever Virus Derived from a Human Survivor

by J. Maximilian Fels, Daniel Maurer, Ana I. Kuehne, Dafna M. Abelson, Noel T. Pauli, Andrew S. Herbert, John M. Dye, Robert W. Cross, Thomas W. Geisbert, Leslie Lobel, Zachary A. Bornholdt, Laura M. Walker, Kartik Chandran
Published 2020-07-01

Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism.

by Shridhar Bale, Jean-Philippe Julien, Zachary A Bornholdt, Christopher R Kimberlin, Peter Halfmann, Michelle A Zandonatti, John Kunert, Gerard J A Kroon, Yoshihiro Kawaoka, Ian J MacRae, Ian A Wilson, Erica Ollmann Saphire
Published 2012-09-01

Combination therapy protects macaques against advanced Marburg virus disease

by Robert W. Cross, Zachary A. Bornholdt, Abhishek N. Prasad, Viktoriya Borisevich, Krystle N. Agans, Daniel J. Deer, Dafna M. Abelson, Do H. Kim, William S. Shestowsky, Lioudmila A. Campbell, Elaine Bunyan, Joan B. Geisbert, Karla A. Fenton, Larry Zeitlin, Danielle P. Porter, Thomas W. Geisbert
Published 2021-03-01