Vascular Senescence in Cardiovascular and Metabolic Diseases

by Goro Katsuumi, Ippei Shimizu, Ippei Shimizu, Yohko Yoshida, Yohko Yoshida, Tohru Minamino
Published 2018-03-01

Haploinsufficiency of akt1 prolongs the lifespan of mice.

by Aika Nojima, Masakatsu Yamashita, Yohko Yoshida, Ippei Shimizu, Harumi Ichimiya, Naomi Kamimura, Yoshio Kobayashi, Shigeo Ohta, Naoaki Ishii, Tohru Minamino
Published 2013-01-01

Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health.

by Ryo Furuuchi, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Masayoshi Suda, Goro Katsuumi, Takayuki Wakasugi, Masaaki Nakao, Tohru Minamino
Published 2018-01-01

Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway.

by Masayoshi Suda, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Goro Katsuumi, Takayuki Wakasugi, Yutaka Yoshida, Shujiro Okuda, Tomoyoshi Soga, Tohru Minamino
Published 2017-01-01

Empagliflozin maintains capillarization and improves cardiac function in a murine model of left ventricular pressure overload

by Masaaki Nakao, Ippei Shimizu, Goro Katsuumi, Yohko Yoshida, Masayoshi Suda, Yuka Hayashi, Ryutaro Ikegami, Yung Ting Hsiao, Shujiro Okuda, Tomoyoshi Soga, Tohru Minamino
Published 2021-09-01

Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway.

by Yohko Yoshida, Yuka Hayashi, Masayoshi Suda, Kaoru Tateno, Sho Okada, Junji Moriya, Masataka Yokoyama, Aika Nojima, Masakatsu Yamashita, Yoshio Kobayashi, Ippei Shimizu, Tohru Minamino
Published 2014-01-01

A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis.

by Takashi K Ito, Masataka Yokoyama, Yohko Yoshida, Aika Nojima, Hidetoshi Kassai, Kengo Oishi, Sho Okada, Daisuke Kinoshita, Yoshio Kobayashi, Marcus Fruttiger, Atsu Aiba, Tohru Minamino
Published 2014-01-01

Inhibition of Endothelial p53 Improves Metabolic Abnormalities Related to Dietary Obesity

by Masataka Yokoyama, Sho Okada, Atsushi Nakagomi, Junji Moriya, Ippei Shimizu, Aika Nojima, Yohko Yoshida, Harumi Ichimiya, Naomi Kamimura, Yoshio Kobayashi, Shigeo Ohta, Marcus Fruttiger, Guillermina Lozano, Tohru Minamino
Published 2014-06-01

Role of smooth muscle cell p53 in pulmonary arterial hypertension.

by Takayuki Wakasugi, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Masayoshi Suda, Goro Katsuumi, Masaaki Nakao, Makoto Hoyano, Takeshi Kashimura, Kazufumi Nakamura, Hiroshi Ito, Takashi Nojiri, Tomoyoshi Soga, Tohru Minamino
Published 2019-01-01

Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy

by Yung Ting Hsiao, Ippei Shimizu, Takayuki Wakasugi, Yohko Yoshida, Ryutaro Ikegami, Yuka Hayashi, Masayoshi Suda, Goro Katsuumi, Masaaki Nakao, Takuya Ozawa, Daisuke Izumi, Takeshi Kashimura, Kazuyuki Ozaki, Tomoyoshi Soga, Tohru Minamino
Published 2021-03-01

Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity

by Ryutaro Ikegami, Ippei Shimizu, Takeshi Sato, Yohko Yoshida, Yuka Hayashi, Masayoshi Suda, Goro Katsuumi, Ji Li, Takayuki Wakasugi, Yasuhiko Minokoshi, Shiki Okamoto, Eiichi Hinoi, Søren Nielsen, Naja Zenius Jespersen, Camilla Scheele, Tomoyoshi Soga, Tohru Minamino
Published 2018-09-01