Immunogenicity Studies of Bivalent Inactivated Virions of EV71/CVA16 Formulated with Submicron Emulsion Systems

by Chih-Wei Lin, Chia-Chyi Liu, Tsung-Chun Lu, Shih-Jen Liu, Yen-Hung Chow, Pele Chong, Ming-Hsi Huang
Published 2014-01-01

The mature EV71 virion induced a broadly cross-neutralizing VP1 antibody against subtypes of the EV71 virus.

by Chia-Ying Wu, Shu-Ling Yu, Yung-Tsung Chen, Yi-Hsuan Chen, Pei-Wen Hsiao, Yen-Hung Chow, Juine-Ruey Chen
Published 2019-01-01

A CpG-adjuvanted intranasal enterovirus 71 vaccine elicits mucosal and systemic immune responses and protects human SCARB2-transgenic mice against lethal challenge

by Yu-Li Lin, Yen-Hung Chow, Li-Min Huang, Szu-Min Hsieh, Pei-Yun Cheng, Kai-Chieh Hu, Bor-Luen Chiang
Published 2018-07-01

Protective efficacy of VP1-specific neutralizing antibody associated with a reduction of viral load and pro-inflammatory cytokines in human SCARB2-transgenic mice.

by Hsuen-Wen Chang, Yi-Wen Lin, Hui-Min Ho, Min-Han Lin, Chia-Chyi Liu, Hsiao-Yun Shao, Pele Chong, Charles Sia, Yen-Hung Chow
Published 2013-01-01

Depletion of regulatory T-cells leads to moderate B-cell antigenicity in respiratory syncytial virus infection

by Hsiao-Yun Shao, Juo-Yu Huang, Yi-Wen Lin, Shu-Ling Yu, Ebenezer Chitra, Ching-Kun Chang, Wang-Chou Sung, Pele Chong, Yen-Hung Chow
Published 2015-12-01

Characterization of a transgenic mouse model exhibiting spontaneous lung adenocarcinomas with a metastatic phenotype.

by Hsuen-Wen Chang, Zih-Miao Lin, Min-Ju Wu, Li-Yu Wang, Yen-Hung Chow, Shih Sheng Jiang, Hui-Ju Ch'ang, Vincent Hs Chang
Published 2017-01-01

Human SCARB2-mediated entry and endocytosis of EV71.

by Yi-Wen Lin, Hsiang-Yin Lin, Yueh-Liang Tsou, Ebenezer Chitra, Kuang-Nan Hsiao, Hsiao-Yun Shao, Chia-Chyi Liu, Charles Sia, Pele Chong, Yen-Hung Chow
Published 2012-01-01

Recombinant adeno-vaccine expressing enterovirus 71-like particles against hand, foot, and mouth disease.

by Yueh-Liang Tsou, Yi-Wen Lin, Hsiao-Yun Shao, Shu-Ling Yu, Shang-Rung Wu, Hsiao-Yu Lin, Chia-Chyi Liu, Chieh Huang, Pele Chong, Yen-Hung Chow
Published 2015-04-01

Heat shock protein 90: role in enterovirus 71 entry and assembly and potential target for therapy.

by Yueh-Liang Tsou, Yi-Wen Lin, Hsuen-Wen Chang, Hsiang-Yin Lin, Hsiao-Yun Shao, Shu-Ling Yu, Chia-Chyi Liu, Ebenezer Chitra, Charles Sia, Yen-Hung Chow
Published 2013-01-01

Therapeutic Effect of Repurposed Temsirolimus in Lung Adenocarcinoma Model

by Hsuen-Wen Chang, Min-Ju Wu, Zih-Miao Lin, Chueh-Yi Wang, Shu-Yun Cheng, Yen-Kuang Lin, Yen-Hung Chow, Hui-Ju Ch’ang, Vincent H. S. Chang
Published 2018-07-01

Immunoprotectivity of HLA-A2 CTL peptides derived from respiratory syncytial virus fusion protein in HLA-A2 transgenic mouse.

by Hsiao-Yun Shao, Yi-Wen Lin, Shu-Ling Yu, Hsiang-Yin Lin, Ebenezer Chitra, Yung-Chen Chang, Charles Sia, Pele Chong, Ming-Tao Hsu, Olivia L Wei, Yen-Hung Chow
Published 2011-01-01

Human SCARB2 transgenic mice as an infectious animal model for enterovirus 71.

by Yi-Wen Lin, Shu-Ling Yu, Hsiao-Yun Shao, Hsiang-Yin Lin, Chia-Chyi Liu, Kuang-Nan Hsiao, Ebenezer Chitra, Yueh-Liang Tsou, Hsuen-Wen Chang, Charles Sia, Pele Chong, Yen-Hung Chow
Published 2013-01-01

Long-term immunogenicity studies of formalin-inactivated enterovirus 71 whole-virion vaccine in macaques.

by Chia-Chyi Liu, Chyi-Sing Hwang, Wun-Syue Yang, Dan-Chin Tsai, Sze-Hsien Wu, Ai-Hsiang Chou, Yen-Hung Chow, Suh-Chin Wu, Jen-Ren Wang, Jen-Ron Chiang, Chin-Cheng Huang, Chien-Hsiung Pan, Pele Chong
Published 2014-01-01

Inactivated Enterovirus 71 Vaccine Produced by 200-L Scale Serum-Free Microcarrier Bioreactor System Provides Cross-Protective Efficacy in Human SCARB2 Transgenic Mouse.

by Chia-Ying Wu, Yi-Wen Lin, Chia-Ho Kuo, Wan-Hsin Liu, Hsiu-Fen Tai, Chien-Hung Pan, Yung-Tsung Chen, Pei-Wen Hsiao, Chi-Hsien Chan, Ching-Chuan Chang, Chung-Cheng Liu, Yen-Hung Chow, Juine-Ruey Chen
Published 2015-01-01

Immunological Evaluation and Comparison of Different EV71 Vaccine Candidates

by Ai-Hsiang Chou, Chia-Chyi Liu, Jui-Yuan Chang, Shu-Pei Lien, Meng-Shin Guo, Hau-Pong Tasi, Kuang-Nan Hsiao, Shih-Jen Liu, Charles Sia, Suh-Chin Wu, Min-Shi Lee, Chia-Hsin Hsiao, Jen-Ren Wang, Yen-Hung Chow, Pele Chong
Published 2012-01-01

Pilot scale production of highly efficacious and stable enterovirus 71 vaccine candidates.

by Ai-Hsiang Chou, Chia-Chyi Liu, Cheng-Peng Chang, Meng-Shin Guo, Shih-Yang Hsieh, Wen-Hsueh Yang, Hsin-Ju Chao, Chien-Long Wu, Ju-Lan Huang, Min-Shi Lee, Alan Yung-Chi Hu, Sue-Chen Lin, Yu-Yun Huang, Mei-Hua Hu, Yen-Hung Chow, Jen-Ron Chiang, Jui-Yuan Chang, Pele Chong
Published 2012-01-01