QT PRODACT: In Vivo QT Assay in Anesthetized Dog for Detecting the Potential for QT Interval Prolongation by Human Pharmaceuticals

by Hiroyuki Tashibu, Hiroyasu Miyazaki, Kumiko Aoki, Yasuki Akie, Keiji Yamamoto
Published 2005-01-01

Halothane Sensitizes the Guinea-Pig Heart to Pharmacological IKr Blockade: Comparison With Urethane Anesthesia

by Yasue Sakaguchi, Atsushi Sugiyama, Shuji Takao, Yasuki Akie, Akira Takahara, Keitaro Hashimoto
Published 2005-01-01

Measurements of Cardiac Ion Channel Subunits in the Chronic Atrioventricular Block Dog

by Akira Takahara, Hirotaka Wagatsuma, Shizuka Aritomi, Tomoyuki Konda, Yasuki Akie, Yuji Nakamura, Atsushi Sugiyama
Published 2011-01-01

Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventr...

by Atsushi Sugiyama, Yuji Nakamura, Yasuki Akie, Hiroyuki Saito, Yasukatsu Izumi, Hiroshi Yamazaki, Naoki Kaneko, Katzuhiko Itoh
Published 2011-01-01

Use of microminipigs for unveiling unknown mechanisms of azithromycin-induced cardiovascular death

by Ai Goto, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kumiko Kitta, Kiyotaka Hoshiai, Koki Chiba, Kentaro Ando, Yasuki Akie, Atsuhiko T. Naito, Atsushi Sugiyama
Published 2018-11-01

In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs

by Hiroyuki Saito, Ryuichi Kambayashi, Ai Goto, Mihoko Hagiwara-Nagasawa, Kiyotaka Hoshiai, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Yasuki Akie, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama
Published 2021-03-01

In vivo comparison of dl-sotalol-induced electrocardiographic responses among halothane anesthesia, isoflurane anesthesia with nitrous oxide, and conscious state

by Hiroyuki Saito, Ryuichi Kambayashi, Mihoko Hagiwara-Nagasawa, Yoshio Nunoi, Ai Goto, Hiroko Izumi-Nakaseko, Shinichi Kawai, Yoshinori Takei, Akio Matsumoto, Kiyotaka Hoshiai, Yasuki Akie, Atsushi Sugiyama
Published 2021-01-01

Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs

by Kentaro Ando, Akira Takahara, Yuji Nakamura, Takeshi Wada, Koki Chiba, Ai Goto, Nur Jaharat Lubna, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kiyotaka Hoshiai, Yasuki Akie, Atsuhiko T. Naito, Atsushi Sugiyama
Published 2018-02-01