Recombinant Factor IX Fc Fusion Protein Maintains Full Procoagulant Properties and Exhibits Prolonged Efficacy in Hemophilia B Mice.

by Garabet G Toby, Tongyao Liu, Yang Buyue, Xin Zhang, Alan J Bitonti, Glenn F Pierce, Jurg M Sommer, Haiyan Jiang, Robert T Peters
Published 2016-01-01

A single chain variant of factor VIII Fc fusion protein retains normal in vivo efficacy but exhibits altered in vitro activity.

by Yang Buyue, Tongyao Liu, John D Kulman, Garabet G Toby, George D Kamphaus, Susannah Patarroyo-White, Qi Lu, Thomas J Reidy, Baisong Mei, Haiyan Jiang, Glenn F Pierce, Jurg M Sommer, Robert T Peters
Published 2014-01-01