Article disease severity human restless legs syndrome sleep disorder Adrenoleukodystrophy Adrenomyeloneuropathy Analgesics, Opioid Anxiety COVID-19 Depression Generalized Anxiety Disorder-7 Humans Insomnia Insomnia Severity Index International Restless Legs Syndrome Study Group Severity Scale Myelopathy Pandemics Patient Health Questionnaire 9 RLS Registries Restless Legs Syndrome Restless legs syndrome Severity of Illness Index Surveys and Questionnaires X linked adrenoleukodystrophy adrenoleukodystrophy adult anxiety disorder clinical article