Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport

by Takashi Kuwano, Xin Bi, Eleonora Cipollari, Tomoyuki Yasuda, William R. Lagor, Hannah J. Szapary, Junichiro Tohyama, John S. Millar, Jeffrey T. Billheimer, Nicholas N. Lyssenko, Daniel J. Rader
Published 2017-04-01

A Self-Deleting AAV-CRISPR System for In Vivo Genome Editing

by Ang Li, Ciaran M. Lee, Ayrea E. Hurley, Kelsey E. Jarrett, Marco De Giorgi, Weiqi Lu, Karol S. Balderrama, Alexandria M. Doerfler, Harshavardhan Deshmukh, Anirban Ray, Gang Bao, William R. Lagor
Published 2019-03-01

Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase

by Marco De Giorgi, Kelsey E. Jarrett, Jason C. Burton, Alexandria M. Doerfler, Ayrea Hurley, Ang Li, Rachel H. Hsu, Mia Furgurson, Kalyani R. Patel, Jun Han, Christoph H. Borchers, William R. Lagor
Published 2020-12-01

Targeting the Apoa1 locus for liver-directed gene therapy

by Marco De Giorgi, Ang Li, Ayrea Hurley, Mercedes Barzi, Alexandria M. Doerfler, Nikitha A. Cherayil, Harrison E. Smith, Jonathan D. Brown, Charles Y. Lin, Karl-Dimiter Bissig, Gang Bao, William R. Lagor
Published 2021-06-01

The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.

by William R Lagor, David W Fields, Sumeet A Khetarpal, Arthi Kumaravel, Wen Lin, Nathaniel Weintraub, Kaijin Wu, Sarah F Hamm-Alvarez, Denise Drazul-Schrader, Margarita de la Llera-Moya, George H Rothblat, Daniel J Rader
Published 2012-01-01

TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

by Chunmei Wang, Yanlin He, Pingwen Xu, Yongjie Yang, Kenji Saito, Yan Xia, Xiaofeng Yan, Antentor Hinton Jr, Chunling Yan, Hongfang Ding, Likai Yu, Gang Shu, Rajat Gupta, Qi Wu, Qingchun Tong, William R. Lagor, Elsa R. Flores, Yong Xu
Published 2018-04-01

A chemical chaperone improves muscle function in mice with a RyR1 mutation

by Chang Seok Lee, Amy D. Hanna, Hui Wang, Adan Dagnino-Acosta, Aditya D. Joshi, Mark Knoblauch, Yan Xia, Dimitra K. Georgiou, Jianjun Xu, Cheng Long, Hisayuki Amano, Corey Reynolds, Keke Dong, John C. Martin, William R. Lagor, George G. Rodney, Ergun Sahin, Caroline Sewry, Susan L. Hamilton
Published 2017-03-01

TFEB regulates murine liver cell fate during development and regeneration

by Nunzia Pastore, Tuong Huynh, Niculin J. Herz, Alessia Calcagni’, Tiemo J. Klisch, Lorenzo Brunetti, Kangho Ho Kim, Marco De Giorgi, Ayrea Hurley, Annamaria Carissimo, Margherita Mutarelli, Niya Aleksieva, Luca D’Orsi, William R. Lagor, David D. Moore, Carmine Settembre, Milton J. Finegold, Stuart J. Forbes, Andrea Ballabio
Published 2020-05-01

A human liver chimeric mouse model for non-alcoholic fatty liver disease

by Beatrice Bissig-Choisat, Michele Alves-Bezerra, Barry Zorman, Scott A. Ochsner, Mercedes Barzi, Xavier Legras, Diane Yang, Malgorzata Borowiak, Adam M. Dean, Robert B. York, N. Thao N. Galvan, John Goss, William R. Lagor, David D. Moore, David E. Cohen, Neil J. McKenna, Pavel Sumazin, Karl-Dimiter Bissig
Published 2021-06-01