Stepwise Reversion of Multiply Mutated Recombinant Antitrypsin Reveals a Selective Inhibitor of Coagulation Factor XIa as Active as the M358R Variant

by Mostafa Hamada, Varsha Bhakta, Sara N. Andres, William P. Sheffield, William P. Sheffield
Published 2021-03-01

A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss

by William P. Sheffield, Louise J. Eltringham-Smith, Varsha Bhakta
Published 2018-04-01

Fusion to Human Serum Albumin Extends the Circulatory Half-Life and Duration of Antithrombotic Action of the Kunitz Protease Inhibitor Domain of Protease Nexin 2

by William P. Sheffield, Louise J. Eltringham-Smith, Varsha Bhakta
Published 2018-02-01

Identification of an alpha-1 antitrypsin variant with enhanced specificity for factor XIa by phage display, bacterial expression, and combinatorial mutagenesis

by Varsha Bhakta, Mostafa Hamada, Amy Nouanesengsy, Jessica Lapierre, Darian L. Perruzza, William P. Sheffield
Published 2021-03-01

Correction: Phage Display of the Serpin Alpha-1 Proteinase Inhibitor Randomized at Consecutive Residues in the Reactive Centre Loop and Biopanned with or without Thrombin.

by Benjamin M Scott, Wadim L Matochko, Richard F Gierczak, Varsha Bhakta, Ratmir Derda, William P Sheffield
Published 2020-01-01

Correction: Phage Display of the Serpin Alpha-1 Proteinase Inhibitor Randomized at Consecutive Residues in the Reactive Centre Loop and Biopanned with or without Thrombin

by Benjamin M. Scott, Wadim L. Matochko, Richard F. Gierczak, Varsha Bhakta, Ratmir Derda, William P. Sheffield
Published 2020-01-01

Phage display of the serpin alpha-1 proteinase inhibitor randomized at consecutive residues in the reactive centre loop and biopanned with or without thrombin.

by Benjamin M Scott, Wadim L Matochko, Richard F Gierczak, Varsha Bhakta, Ratmir Derda, William P Sheffield
Published 2014-01-01

Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa

by David A. Donkor, Varsha Bhakta, Louise J. Eltringham-Smith, Alan R. Stafford, Jeffrey I. Weitz, William P. Sheffield
Published 2017-05-01

In Vivo Clearance of Alpha-1 Acid Glycoprotein Is Influenced by the Extent of Its N-Linked Glycosylation and by Its Interaction with the Vessel Wall

by Teresa R. McCurdy, Varsha Bhakta, Louise J. Eltringham-Smith, Sharon Gataiance, Alison E. Fox-Robichaud, William P. Sheffield
Published 2012-01-01

Comparison of Methods for the Purification of Alpha-1 Acid Glycoprotein from Human Plasma

by Teresa R. McCurdy, Varsha Bhakta, Louise J. Eltringham-Smith, Sharon Gataiance, Alison E. Fox-Robichaud, William P. Sheffield
Published 2011-01-01

Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells

by Rosi Bissinger, Polina Petkova-Kirova, Olga Mykhailova, Per-Arne Oldenborg, Elena Novikova, David A. Donkor, Thomas Dietz, Abdulla Al Mamun Bhuyan, William P. Sheffield, Marijke Grau, Ferruh Artunc, Lars Kaestner, Jason P. Acker, Syed M. Qadri
Published 2020-09-01