Epistatic Interactions within the Influenza A Virus Polymerase Complex Mediate Mutagen Resistance and Replication Fidelity

by Matthew D. Pauly, Daniel M. Lyons, William J. Fitzsimmons, Adam S. Lauring, W. Paul Duprex
Published 2017-08-01

Temporal dynamics of SARS-CoV-2 mutation accumulation within and across infected hosts.

by Andrew L Valesano, Kalee E Rumfelt, Derek E Dimcheff, Christopher N Blair, William J Fitzsimmons, Joshua G Petrie, Emily T Martin, Adam S Lauring
Published 2021-04-01

A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus.

by William J Fitzsimmons, Robert J Woods, John T McCrone, Andrew Woodman, Jamie J Arnold, Madhumita Yennawar, Richard Evans, Craig E Cameron, Adam S Lauring
Published 2018-06-01

Pre-existing heterosubtypic immunity provides a barrier to airborne transmission of influenza viruses.

by Valerie Le Sage, Jennifer E Jones, Karen A Kormuth, William J Fitzsimmons, Eric Nturibi, Gabriella H Padovani, Claudia P Arevalo, Andrea J French, Annika J Avery, Richard Manivanh, Elizabeth E McGrady, Amar R Bhagwat, Adam S Lauring, Scott E Hensley, Seema S Lakdawala
Published 2021-02-01