Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells.

by John C Panetta, Alex Sparreboom, Ching-Hon Pui, Mary V Relling, William E Evans
Published 2010-12-01

Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models.

by Seth E Karol, Laura J Janke, John C Panetta, Laura B Ramsey, Xiangjun Cai, Monique A Payton, David A Jenkins, William E Evans, Mary V Relling
Published 2019-01-01

Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells

by Jesse Bakke, William C. Wright, Anthony E. Zamora, Peter Oladimeji, Jeremy Chase Crawford, Christopher T. Brewer, Robert J. Autry, William E. Evans, Paul G. Thomas, Taosheng Chen
Published 2019-03-01

Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs.

by Deborah French, Wenjian Yang, Leo H Hamilton, Geoffrey Neale, Yiping Fan, James R Downing, Nancy J Cox, Ching-Hon Pui, William E Evans, Mary V Relling
Published 2008-05-01

Fluoroquinolone prophylaxis does not increase risk of neuropathy in children with acute lymphoblastic leukemia

by Seth E. Karol, Yilun Sun, Li Tang, Ching‐Hon Pui, Jose Ferrolino, Kim J. Allison, Shane J. Cross, William E. Evans, Kristine R. Crews, Sima Jeha, Joshua Wolf
Published 2020-09-01

In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile.

by Michael J Sorich, Nicolas Pottier, Deqing Pei, Wenjian Yang, Leo Kager, Gabriele Stocco, Cheng Cheng, John C Panetta, Ching-Hon Pui, Mary V Relling, Meyling H Cheok, William E Evans
Published 2008-04-01

Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia.

by Laura B Ramsey, Laura J Janke, Monique A Payton, Xiangjun Cai, Steven W Paugh, Seth E Karol, Landry Kamdem Kamdem, Cheng Cheng, Richard T Williams, Sima Jeha, Ching-Hon Pui, William E Evans, Mary V Relling
Published 2015-01-01

MicroRNAs Form Triplexes with Double Stranded DNA at Sequence-Specific Binding Sites; a Eukaryotic Mechanism via which microRNAs Could Directly Alter Gene Expression.

by Steven W Paugh, David R Coss, Ju Bao, Lucas T Laudermilk, Christy R Grace, Antonio M Ferreira, M Brett Waddell, Granger Ridout, Deanna Naeve, Michael Leuze, Philip F LoCascio, John C Panetta, Mark R Wilkinson, Ching-Hon Pui, Clayton W Naeve, Edward C Uberbacher, Erik J Bonten, William E Evans
Published 2016-02-01

Population Pharmacokinetics of Vincristine Related to Infusion Duration and Peripheral Neuropathy in Pediatric Oncology Patients

by Mirjam Esther van de Velde, John Carl. Panetta, Abraham J. Wilhelm, Marleen H. van den Berg, Inge M. van der Sluis, Cor van den Bos, Floor C.H. Abbink, Marry M. van den Heuvel-Eibrink, Heidi Segers, Christophe Chantrain, Jutte van der Werff Ten Bosch, Leen Willems, William E. Evans, Gertjan L. Kaspers
Published 2020-07-01

Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk

by Jayaram Vijayakrishnan, Maoxiang Qian, James B. Studd, Wenjian Yang, Ben Kinnersley, Philip J. Law, Peter Broderick, Elizabeth A. Raetz, James Allan, Ching-Hon Pui, Ajay Vora, William E. Evans, Anthony Moorman, Allen Yeoh, Wentao Yang, Chunliang Li, Claus R. Bartram, Charles G. Mullighan, Martin Zimmerman, Stephen P. Hunger, Martin Schrappe, Mary V. Relling, Martin Stanulla, Mignon L. Loh, Richard S. Houlston, Jun J. Yang
Published 2019-11-01

Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine

by Barthelemy Diouf, Claudia Wing, John C. Panetta, Donnie Eddins, Wenwei Lin, Wenjian Yang, Yiping Fan, Deqing Pei, Cheng Cheng, Shannon M. Delaney, Wei Zhang, Erik J. Bonten, Kristine R. Crews, Steven W. Paugh, Lie Li, Burgess B. Freeman 3rd, Robert J. Autry, Jordan A. Beard, Daniel C. Ferguson, Laura J. Janke, Kirsten K. Ness, Taosheng Chen, Stanislav S. Zakharenko, Sima Jeha, Ching‐Hon Pui, Mary V. Relling, M. Eileen Dolan, William E. Evans
Published 2021-07-01