Adrenal Cortex Hormones Aged Aged, 80 and over Article Cohort Studies Disease Progression Female Global Health Health Care Costs Humans Male Middle Aged Muscarinic Antagonists Patient Acceptance of Health Care Patient Compliance Practice Guidelines as Topic Pulmonary Disease, Chronic Obstructive Retrospective Studies Treatment Outcome aged antibiotic agent antibiotic therapy beta 2 adrenergic receptor stimulating agent chronic obstructive lung disease clinical evaluation cohort analysis comparative study controlled study corticosteroid disease classification