Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei

by Wenxu Zhou, George A.M. Cross, W. David Nes
Published 2007-03-01

Structural requirements for substrate recognition of Mycobacterium tuberculosis 14α-demethylase: implications for sterol biosynthesis

by Aouatef Bellamine, Anil T. Mangla, Allen L. Dennis, W. David Nes, Michael R. Waterman
Published 2001-01-01

Evolutionarily conserved Δ25(27)-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii

by Matthew B. Miller, Brad A. Haubrich, Qian Wang, William J. Snell, W. David Nes
Published 2012-08-01

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol

by Tatiana Y. Hargrove, Zdzislaw Wawrzak, Jialin Liu, Michael R. Waterman, W. David Nes, Galina I. Lepesheva
Published 2012-02-01

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri.

by Wenxu Zhou, Anjan Debnath, Gareth Jennings, Hye Jee Hahn, Boden H Vanderloop, Minu Chaudhuri, W David Nes, Larissa M Podust
Published 2018-09-01

Mechanism-based Enzyme Inactivators of Phytosterol Biosynthesis

by W. David Nes, Mathew B. Miller, Phani Veeramachanemi, Archana Sinha, Pruthvi Jayasimha, Jialin Liu, Ragu Kanagasabai, Zhihong Song, Wenxu Zhou
Published 2004-03-01

Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design

by Medhanie E. Kidane, Boden H. Vanderloop, Wenxu Zhou, Crista D. Thomas, Emilio Ramos, Ujjal Singha, Minu Chaudhuri, W. David Nes
Published 2017-12-01

A nematode sterol C4α-methyltransferase catalyzes a new methylation reaction responsible for sterol diversity[S]

by Wenxu Zhou, Paxtyn M. Fisher, Boden H. Vanderloop, Yun Shen, Huazhong Shi, Adrian J. Maldonado, David J. Leaver, W. David Nes
Published 2020-02-01

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).

by Anjan Debnath, Claudia M Calvet, Gareth Jennings, Wenxu Zhou, Alexander Aksenov, Madeline R Luth, Ruben Abagyan, W David Nes, James H McKerrow, Larissa M Podust
Published 2017-12-01

Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications

by Wenxu Zhou, Emilio Ramos, Xunlu Zhu, Paxtyn M. Fisher, Medhanie E. Kidane, Boden H. Vanderloop, Crista D. Thomas, Juqiang Yan, Ujjal Singha, Minu Chaudhuri, Michael T. Nagel, W.David Nes
Published 2019-05-01

Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth[S]

by Brad A. Haubrich, Ujjal K. Singha, Matthew B. Miller, Craigen R. Nes, Hosanna Anyatonwu, Laurence Lecordier, Presheet Patkar, David J. Leaver, Fernando Villalta, Benoit Vanhollebeke, Minu Chaudhuri, W. David Nes
Published 2015-02-01