APBB1 gene ATP6V1B1 gene Article CIITA gene E2F1 gene HSPA6 gene IKBKE gene IL7R gene ISG15 gene MYD88 gene RNA sequencing ROC analysis SARS-CoV-2 infection SOCS3 gene STAT1 gene TFAP4 gene VCAM1 gene ZBTB16 gene bioinformatics coronavirus disease 2019 diagnostic value differentially expressed genes down regulation drug metabolism gene expression gene function gene ontology gene targeting genetic association molecular pathology