USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy

by Yi-Chang Wang, Yu-Syuan Wu, Chia-Yang Hung, Shao-An Wang, Ming-Jer Young, Tsung-I Hsu, Jan-Jong Hung
Published 2018-09-01

ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade

by Yu-Ting Tsai, An-Chih Wu, Wen-Bin Yang, Tzu-Jen Kao, Jian-Ying Chuang, Wen-Chang Chang, Tsung-I. Hsu
Published 2019-11-01

CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation

by Shao-Ming Wang, Hong-Yi Lin, Yen-Lin Chen, Tsung-I Hsu, Jian-Ying Chuang, Tzu-Jen Kao, Chiung-Yuan Ko
Published 2019-07-01

Betulinic Acid-Mediated Tuning of PERK/CHOP Signaling by Sp1 Inhibition as a Novel Therapeutic Strategy for Glioblastoma

by Wei-Lun Lo, Tsung-I Hsu, Wen-Bin Yang, Tzu-Jen Kao, Ming-Hsiao Wu, Yung-Ning Huang, Shiu-Hwa Yeh, Jian-Ying Chuang
Published 2020-04-01

CYP17A1 Maintains the Survival of Glioblastomas by Regulating SAR1-Mediated Endoplasmic Reticulum Health and Redox Homeostasis

by Hong-Yi Lin, Chiung-Yuan Ko, Tzu-Jen Kao, Wen-Bin Yang, Yu-Ting Tsai, Jian-Ying Chuang, Siou-Lian Hu, Pei-Yu Yang, Wei-Lun Lo, Tsung-I Hsu
Published 2019-09-01

AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

by Tzu-Chi Chen, Jian-Ying Chuang, Chiung-Yuan Ko, Tzu-Jen Kao, Pei-Yu Yang, Chun-Hui Yu, Ming-Sheng Liu, Siou-Lian Hu, Yu-Ting Tsai, Hardy Chan, Wen-Chang Chang, Tsung-I. Hsu
Published 2020-02-01

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress

by Chung-Che Wu, Pin-Tse Lee, Tzu-Jen Kao, Szu-Yi Chou, Ruei-Yuan Su, Yi-Chao Lee, Shiu-Hwa Yeh, Jing-Ping Liou, Tsung-I Hsu, Tsung-Ping Su, Cheng-Keng Chuang, Wen-Chang Chang, Jian-Ying Chuang
Published 2018-10-01

Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells

by Wen-Bin Yang, An-Chih Wu, Tsung-I Hsu, Jing-Ping Liou, Wei-Lun Lo, Kwang-Yu Chang, Pin-Yuan Chen, Ushio Kikkawa, Shung-Tai Yang, Tzu-Jen Kao, Ruei-Ming Chen, Wen-Chang Chang, Chiung-Yuan Ko, Jian-Ying Chuang
Published 2021-09-01

Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase

by Kwang-Yu Chang, Tsung-I. Hsu, Che-Chia Hsu, Shan-Yin Tsai, Jr-Jiun Liu, Shao-Wen Chou, Ming-Sheng Liu, Jing-Ping Liou, Chiung-Yuan Ko, Kai-Yun Chen, Jan-Jong Hung, Wen-Chang Chang, Cheng-Keng Chuang, Tzu-Jen Kao, Jian-Ying Chuang
Published 2017-10-01

NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the β-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhi...

by Cheng-Yu Tsai, Huey-Jiun Ko, Shean-Jaw Chiou, Yu-Ling Lai, Chia-Chung Hou, Tehseen Javaria, Zi-Yi Huang, Tai-Shan Cheng, Tsung-I Hsu, Jian-Ying Chuang, Aij-Lie Kwan, Tsung-Hsien Chuang, Chi-Ying F. Huang, Joon-Khim Loh, Yi-Ren Hong
Published 2021-05-01

Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets

by Chia-Hung Chien, Jian-Ying Chuang, Shun-Tai Yang, Wen-Bin Yang, Pin-Yuan Chen, Tsung-I Hsu, Chih-Yuan Huang, Wei-Lun Lo, Ka-Yen Yang, Ming-Sheng Liu, Jui-Mei Chu, Pei-Hsuan Chung, Jr-Jiun Liu, Shao-Wen Chou, Shang-Hung Chen, Kwang-Yu Chang
Published 2019-10-01

Serum amyloid A1 in combination with integrin αVβ3 increases glioblastoma cells mobility and progression

by Ching‐Yu Lin, Shun‐Tai Yang, Shing‐Chuan Shen, Yi‐Chen Hsieh, Fei‐Ting Hsu, Cheng‐Yu Chen, Yung‐Hsiao Chiang, Jian‐Ying Chuang, Kai‐Yun Chen, Tsung‐I Hsu, Wan‐Chong Leong, Yu‐Kai Su, Wei‐Lun Lo, Yi‐Shian Yeh, Yudha Nur Patria, Hsiu‐Ming Shih, Che‐Chang Chang, Szu‐Yi Chou
Published 2018-05-01