Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model SystemsSummary

by Trenton T. Ross, Collin Crowley, Kenneth L. Kelly, Anthony Rinaldi, David A. Beebe, Matthew P. Lech, Robert V. Martinez, Santos Carvajal-Gonzalez, Magalie Boucher, Dinesh Hirenallur-Shanthappa, Jeffrey Morin, Alan C. Opsahl, Sarah R. Vargas, Kendra K. Bence, Jeffrey A. Pfefferkorn, William P. Esler
Published 2020-01-01

The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats.

by Derek M Erion, Amanda Lapworth, Paul A Amor, Guoyun Bai, Nicholas B Vera, Ronald W Clark, Qingyun Yan, Yimin Zhu, Trenton T Ross, Julie Purkal, Matthew Gorgoglione, Guodong Zhang, Vinicius Bonato, Levenia Baker, Nicole Barucci, Theresa D'Aquila, Alan Robertson, Robert J Aiello, Jiangli Yan, Jeff Trimmer, Timothy P Rolph, Jeffrey A Pfefferkorn
Published 2014-01-01

Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction

by Jemy A. Gutierrez, Wei Liu, Sylvie Perez, Gang Xing, Gabriele Sonnenberg, Kou Kou, Matt Blatnik, Richard Allen, Yan Weng, Nicholas B. Vera, Kristin Chidsey, Arthur Bergman, Veena Somayaji, Collin Crowley, Michelle F. Clasquin, Anu Nigam, Melissa A. Fulham, Derek M. Erion, Trenton T. Ross, William P. Esler, Thomas V. Magee, Jeffrey A. Pfefferkorn, Kendra K. Bence, Morris J. Birnbaum, Gregory J. Tesz
Published 2021-06-01