Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings.

by Xuefang Pan, Yanting Wang, Torben Lübke, Aleksander Hinek, Alexey V Pshezhetsky
Published 2017-01-01

Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1.

by Xuefang Pan, Lubov Grigoryeva, Volkan Seyrantepe, Junzheng Peng, Katrin Kollmann, Johanne Tremblay, Julie L Lavoie, Aleksander Hinek, Torben Lübke, Alexey V Pshezhetsky
Published 2014-02-01

A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease

by Heike Wolf, Markus Damme, Stijn Stroobants, Rudi D'Hooge, Hans Christian Beck, Irm Hermans-Borgmeyer, Renate Lüllmann-Rauch, Thomas Dierks, Torben Lübke
Published 2016-09-01

Sensorimotor and Neurocognitive Dysfunctions Parallel Early Telencephalic Neuropathology in Fucosidosis Mice

by Stijn Stroobants, Stijn Stroobants, Heike Wolf, Zsuzsanna Callaerts-Vegh, Zsuzsanna Callaerts-Vegh, Thomas Dierks, Torben Lübke, Rudi D’Hooge, Rudi D’Hooge
Published 2018-04-01

Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells

by Xiang Y. Kong, Cecilie Kasi Nesset, Markus Damme, Else-Marit Løberg, Torben Lübke, Jan Mæhlen, Kristin B. Andersson, Petra I. Lorenzo, Norbert Roos, G. Hege Thoresen, Arild C. Rustan, Eili T. Kase, Winnie Eskild
Published 2014-03-01