Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases

by Timothy Palzkill, Timothy Palzkill
Published 2018-02-01

Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability.

by Shrenik C Mehta, Kacie Rice, Timothy Palzkill
Published 2015-06-01

How structural and physicochemical determinants shape sequence constraints in a functional enzyme.

by Luciano A Abriata, Timothy Palzkill, Matteo Dal Peraro
Published 2015-01-01

Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics

by Zhizeng Sun, Liya Hu, Banumathi Sankaran, B. V. Venkataram Prasad, Timothy Palzkill
Published 2018-10-01

Development and Evaluation of a Novel Protein-Based Assay for Specific Detection of KPC β-Lactamases from Klebsiella pneumoniae Clinical Isolates

by Shuo Lu, Victoria Soeung, Hoang A. T. Nguyen, S. Wesley Long, James M. Musser, Timothy Palzkill
Published 2020-01-01

Identification and Characterization of Single-Chain Antibodies that Specifically Bind GI Noroviruses.

by Amy M Hurwitz, Wanzhi Huang, Baijun Kou, Mary K Estes, Robert L Atmar, Timothy Palzkill
Published 2017-01-01

The binary protein interactome of Treponema pallidum--the syphilis spirochete.

by Björn Titz, Seesandra V Rajagopala, Johannes Goll, Roman Häuser, Matthew T McKevitt, Timothy Palzkill, Peter Uetz
Published 2008-05-01

Physiological roles of ArcA, Crp, and EtrA and their interactive control on aerobic and anaerobic respiration in Shewanella oneidensis.

by Haichun Gao, Xiaohu Wang, Zamin K Yang, Jingrong Chen, Yili Liang, Haijiang Chen, Timothy Palzkill, Jizhong Zhou
Published 2010-01-01

Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor.

by Fei Yan, Yang Yu, Dar-Chone Chow, Timothy Palzkill, Franck Madoux, Peter Hodder, Peter Chase, Patrick R Griffin, Bert W O'Malley, David M Lonard
Published 2014-01-01

Generation and validation of a Shewanella oneidensis MR-1 clone set for protein expression and phage display.

by Haichun Gao, Donna Pattison, Tingfen Yan, Dawn M Klingeman, Xiaohu Wang, Joseph Petrosino, Lisa Hemphill, Xiufeng Wan, Adam B Leaphart, George M Weinstock, Timothy Palzkill, Jizhong Zhou
Published 2008-01-01

Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding.

by Jeong Joo Kim, Darren E Casteel, Gilbert Huang, Taek Hun Kwon, Ronnie Kuo Ren, Peter Zwart, Jeffrey J Headd, Nicholas Gene Brown, Dar-Chone Chow, Timothy Palzkill, Choel Kim
Published 2011-04-01

DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

by Margie N. Sutton, Zhen Lu, Yao-Cheng Li, Yong Zhou, Tao Huang, Albert S. Reger, Amy M. Hurwitz, Timothy Palzkill, Craig Logsdon, Xiaowen Liang, Joe W. Gray, Xiaolin Nan, John Hancock, Geoffrey M. Wahl, Robert C. Bast, Jr.
Published 2019-12-01

DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1

by Margie N. Sutton, Gilbert Y. Huang, Xiaowen Liang, Rajesh Sharma, Albert S. Reger, Weiqun Mao, Lan Pang, Philip J. Rask, Kwangkook Lee, Joshua P. Gray, Amy M. Hurwitz, Timothy Palzkill, Steven W. Millward, Choel Kim, Zhen Lu, Robert C. Bast
Published 2019-04-01