A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides

by Andreas Dieckmann, Peter H. Hagedorn, Yvonne Burki, Christine Brügmann, Marco Berrera, Martin Ebeling, Thomas Singer, Franz Schuler
Published 2018-03-01

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro.

by Deborah G Nguyen, Juergen Funk, Justin B Robbins, Candace Crogan-Grundy, Sharon C Presnell, Thomas Singer, Adrian B Roth
Published 2016-01-01

Effect of different interferonα2 preparations on IP10 and ET-1 release from human lung cells.

by Rekha Badiger, Jane A Mitchell, Hime Gashaw, Neil A Galloway-Phillipps, Stefan Foser, Fernando Tatsch, Thomas Singer, Trevor T Hansel, Tobias Manigold
Published 2012-01-01

Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs.

by Sabine Sewing, Franziska Boess, Annie Moisan, Cristina Bertinetti-Lapatki, Tanja Minz, Maj Hedtjaern, Yann Tessier, Franz Schuler, Thomas Singer, Adrian B Roth
Published 2016-01-01

Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells

by Maria Cristina de Vera Mudry, Franziska Regenass-Lechner, Laurence Ozmen, Bernd Altmann, Matthias Festag, Thomas Singer, Lutz Müller, Helmut Jacobsen, Alexander Flohr
Published 2012-01-01

Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk

by Mark R. Davies, Michael Martinec, Robert Walls, Roman Schwarz, Gary R. Mirams, Ken Wang, Guido Steiner, Andy Surinach, Carlos Flores, Thierry Lavé, Thomas Singer, Liudmila Polonchuk
Published 2020-08-01

Brain Shuttle Antibody for Alzheimer’s Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode

by Felix Weber, Bernd Bohrmann, Jens Niewoehner, Jens A.A. Fischer, Petra Rueger, Georg Tiefenthaler, Joerg Moelleken, Alexander Bujotzek, Kevin Brady, Thomas Singer, Martin Ebeling, Antonio Iglesias, Per-Ola Freskgård
Published 2018-01-01

Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia.

by Sabine Sewing, Adrian B Roth, Michael Winter, Andreas Dieckmann, Cristina Bertinetti-Lapatki, Yann Tessier, Claudia McGinnis, Sylwia Huber, Erich Koller, Corinne Ploix, John C Reed, Thomas Singer, Andreas Rothfuss
Published 2017-01-01

Culture and Drug Profiling of Patient Derived Malignant Pleural Effusions for Personalized Cancer Medicine.

by Christian Ruiz, Stefan Kustermann, Elina Pietilae, Tatjana Vlajnic, Betty Baschiera, Leila Arabi, Thomas Lorber, Martin Oeggerli, Spasenija Savic, Ellen Obermann, Thomas Singer, Sacha I Rothschild, Alfred Zippelius, Adrian B Roth, Lukas Bubendorf
Published 2016-01-01

Unraveling the deep learning gearbox in optical coherence tomography image segmentation towards explainable artificial intelligence

by Peter M. Maloca, Philipp L. Müller, Aaron Y. Lee, Adnan Tufail, Konstantinos Balaskas, Stephanie Niklaus, Pascal Kaiser, Susanne Suter, Javier Zarranz-Ventura, Catherine Egan, Hendrik P. N. Scholl, Tobias K. Schnitzer, Thomas Singer, Pascal W. Hasler, Nora Denk
Published 2021-02-01

Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling

by Annie Moisan, Marcel Gubler, Jitao David Zhang, Yann Tessier, Kamille Dumong Erichsen, Sabine Sewing, Régine Gérard, Blandine Avignon, Sylwia Huber, Fethallah Benmansour, Xing Chen, Roberto Villaseñor, Annamaria Braendli-Baiocco, Matthias Festag, Andreas Maunz, Thomas Singer, Franz Schuler, Adrian B. Roth
Published 2017-03-01

Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

by S Jordan Kerns, Chaitra Belgur, Debora Petropolis, Marianne Kanellias, Riccardo Barrile, Johannes Sam, Tina Weinzierl, Tanja Fauti, Anne Freimoser-Grundschober, Jan Eckmann, Carina Hage, Martina Geiger, Patrick Ray Ng, William Tien-Street, Dimitris V Manatakis, Virginie Micallef, Regine Gerard, Michael Bscheider, Ekaterina Breous-Nystrom, Anneliese Schneider, Anna Maria Giusti, Cristina Bertinetti-Lapatki, Heather Shannon Grant, Adrian B Roth, Geraldine A Hamilton, Thomas Singer, Katia Karalis, Annie Moisan, Peter Bruenker, Christian Klein, Marina Bacac, Nikolce Gjorevski, Lauriane Cabon
Published 2021-08-01

The effect of pollutants on riverine microbial biofilms

by Lehmann, Katja
Published 2014