In Vitro Inhibition of Insulin Release by Blood Mononuclear Cells from Insulin-Dependent Diabetic and Healthy Subjects: Synergistic Action of IL-1 and TNF

by Vitlaly Ablamunits, Flora Baranova, Thomas Mandrup-Poulsen, Jørn Nerup
Published 1994-01-01

Divalent Metal Transporter 1 Knock-Down Modulates IL-1β Mediated Pancreatic Beta-Cell Pro-Apoptotic Signaling Pathways through the Autophagic Machinery

by Taewook Kang, Honggang Huang, Thomas Mandrup-Poulsen, Martin R. Larsen
Published 2021-07-01

JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis.

by Michala Prause, Dan Ploug Christensen, Nils Billestrup, Thomas Mandrup-Poulsen
Published 2014-01-01

Combination of ferric ammonium citrate with cytokines involved in apoptosis and insulin secretion of human pancreatic beta cells related to diabetes in thalassemia

by Patchara Rattanaporn, Sissades Tongsima, Thomas Mandrup-Poulsen, Saovaros Svasti, Dalina Tanyong
Published 2020-06-01

The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets

by Seyed Mojtaba Ghiasi, Jakob Bondo Hansen, Dan Ploug Christensen, Björn Tyrberg, Thomas Mandrup-Poulsen
Published 2020-06-01

High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression.

by Rikard G Fred, Claus H Bang-Berthelsen, Thomas Mandrup-Poulsen, Lars G Grunnet, Nils Welsh
Published 2010-01-01

JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression

by Michala Prause, Christopher Michael Mayer, Caroline Brorsson, Klaus Stensgaard Frederiksen, Nils Billestrup, Joachim Størling, Thomas Mandrup-Poulsen
Published 2016-01-01

A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats.

by Kirsten M Hoelmkjaer, Nicolai J Wewer Albrechtsen, Jens J Holst, Anna M Cronin, Dorte H Nielsen, Thomas Mandrup-Poulsen, Charlotte R Bjornvad
Published 2016-01-01

Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-Cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases...

by Phillip Alexander Keller Andersen, Volodymyr Petrenko, Peter Horskjær Rose, Melissa Koomen, Nico Fischer, Seyed Mojtaba Ghiasi, Tina Dahlby, Charna Dibner, Thomas Mandrup-Poulsen
Published 2021-12-01

Interleukin-6 receptor blockade or TNFα inhibition for reducing glycaemia in patients with RA and diabetes: post hoc analyses of three randomised, controlled trials

by Mark C. Genovese, Gerd R. Burmester, Owen Hagino, Karthinathan Thangavelu, Melitza Iglesias-Rodriguez, Gregory St John, Miguel A. González-Gay, Thomas Mandrup-Poulsen, Roy Fleischmann
Published 2020-09-01

A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells

by Anna Lindeløv Vestergaard, Maaike Blankestijn, Jonathan Lucien Stahl, Emil Marek Heymans Pallesen, Claus Heiner Bang-Berthelsen, Flemming Pociot, Guy Wayne Novotny, Morten Lundh, Thomas Mandrup-Poulsen
Published 2016-06-01

Tissue Inhibitor Of Matrix Metalloproteinase-1 Is Required for High-Fat Diet-Induced Glucose Intolerance and Hepatic Steatosis in Mice.

by Even Fjære, Charlotte Andersen, Lene Secher Myrmel, Rasmus Koefoed Petersen, Jakob Bondo Hansen, Hanne Sørup Tastesen, Thomas Mandrup-Poulsen, Nils Brünner, Karsten Kristiansen, Lise Madsen, Maria Unni Rømer
Published 2015-01-01

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

by Marie Balslev Backe, Chunyu Jin, Luz Andreone, Aditya Sankar, Karl Agger, Kristian Helin, Andreas Nygaard Madsen, Steen Seier Poulsen, Madhusudhan Bysani, Karl Bacos, Charlotte Ling, Marcelo Javier Perone, Birgitte Holst, Thomas Mandrup-Poulsen
Published 2019-01-01

Mitophagy protects β cells from inflammatory damage in diabetes

by Vaibhav Sidarala, Gemma L. Pearson, Vishal S. Parekh, Benjamin Thompson, Lisa Christen, Morgan A. Gingerich, Jie Zhu, Tracy Stromer, Jianhua Ren, Emma C. Reck, Biaoxin Chai, John A. Corbett, Thomas Mandrup-Poulsen, Leslie S. Satin, Scott A. Soleimanpour
Published 2020-12-01

The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β.

by Muhammad Saad Khilji, Danielle Verstappen, Tina Dahlby, Michala Cecilie Burstein Prause, Celina Pihl, Sophie Emilie Bresson, Tenna Holgersen Bryde, Phillip Alexander Keller Andersen, Kristian Klindt, Dusan Zivkovic, Marie-Pierre Bousquet-Dubouch, Björn Tyrberg, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
Published 2020-01-01

MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage.

by Anna Lindeløv Vestergaard, Claus Heiner Bang-Berthelsen, Tina Fløyel, Jonathan Lucien Stahl, Lisa Christen, Farzaneh Taheri Sotudeh, Peter de Hemmer Horskjær, Klaus Stensgaard Frederiksen, Frida Greek Kofod, Christine Bruun, Lukas Adrian Berchtold, Joachim Størling, Romano Regazzi, Simranjeet Kaur, Flemming Pociot, Thomas Mandrup-Poulsen
Published 2018-01-01

Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

by Anniek F. Lubberding, Jinyi Zhang, Morten Lundh, Thomas Svava Nielsen, Mathilde S. Søndergaard, Maria Villadsen, Emil Z. Skovhøj, Geke A. Boer, Jakob B. Hansen, Morten B. Thomsen, Jonas T. Treebak, Jens J. Holst, Jørgen K. Kanters, Thomas Mandrup-Poulsen, Thomas Jespersen, Brice Emanuelli, Signe S. Torekov
Published 2021-06-01

GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity

by Stacey Bartlett, Adrian Tandhyka Gemiarto, Minh Dao Ngo, Haressh Sajiir, Semira Hailu, Roma Sinha, Cheng Xiang Foo, Léanie Kleynhans, Happy Tshivhula, Tariq Webber, Helle Bielefeldt-Ohmann, Helle Bielefeldt-Ohmann, Nicholas P. West, Nicholas P. West, Andriette M. Hiemstra, Candice E. MacDonald, Liv von Voss Christensen, Larry S. Schlesinger, Gerhard Walzl, Mette Marie Rosenkilde, Thomas Mandrup-Poulsen, Katharina Ronacher, Katharina Ronacher, Katharina Ronacher
Published 2020-11-01