A gratuitous β-Lactamase inducer uncovers hidden active site dynamics of the Staphylococcus aureus BlaR1 sensor domain.

by Thomas E Frederick, Jeffrey W Peng
Published 2018-01-01

Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators.

by Kathryn M Hart, Katelyn E Moeder, Chris M W Ho, Maxwell I Zimmerman, Thomas E Frederick, Gregory R Bowman
Published 2017-01-01

Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models

by Maxwell I. Zimmerman, Kathryn M. Hart, Carrie A. Sibbald, Thomas E. Frederick, John R. Jimah, Catherine R. Knoverek, Niraj H. Tolia, Gregory R. Bowman
Published 2017-11-01

The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target

by Wenjie Wang, Woo-Jin Shin, Bojie Zhang, Younho Choi, Ji-Seung Yoo, Maxwell I. Zimmerman, Thomas E. Frederick, Gregory R. Bowman, Michael L. Gross, Daisy W. Leung, Jae U. Jung, Gaya K. Amarasinghe
Published 2020-01-01