The Divergent CD8+ T Cell Adjuvant Properties of LT-IIb and LT-IIc, Two Type II Heat-Labile Enterotoxins, Are Conferred by Their Ganglioside-Binding B Subunits.

by John C Hu, Christopher J Greene, Natalie D King-Lyons, Terry D Connell
Published 2015-01-01

Intradermal administration of the Type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances humoral and CD8+ T cell immunity to a co-administe...

by John C Hu, Camila Mathias-Santos, Christopher J Greene, Natalie D King-Lyons, Juliana F Rodrigues, George Hajishengallis, Luís C S Ferreira, Terry D Connell
Published 2014-01-01

LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity.

by Christopher J Greene, Chrystal M Chadwick, Lorrie M Mandell, John C Hu, Joanne M O'Hara, Robert N Brey, Nicholas J Mantis, Terry D Connell
Published 2013-01-01

LT-IIc, A Bacterial Type II Heat-Labile Enterotoxin, Induces Specific Lethality in Triple Negative Breast Cancer Cells by Modulation of Autophagy and Induction of Apoptosis and Nec...

by Patricia Masso-Welch, Sofia Girald Berlingeri, Natalie D. King-Lyons, Lorrie Mandell, John Hu, Christopher J. Greene, Matthew Federowicz, Peter Cao, Terry D. Connell, Yasser Heakal
Published 2018-12-01

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy

by Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader
Published 2016-12-01