Heat Shock Proteins as Immunomodulants

by Tawanda Zininga, Lebogang Ramatsui, Addmore Shonhai
Published 2018-11-01

The Link That Binds: The Linker of Hsp70 as a Helm of the Protein’s Function

by Graham Chakafana, Tawanda Zininga, Addmore Shonhai
Published 2019-09-01

Supporting data on characterisation of linker switch mutants of Plasmodium falciparum heat shock protein 110 and canonical Hsp70

by Graham Chakafana, Pertunia T. Mudau, Tawanda Zininga, Addmore Shonhai
Published 2021-08-01

Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers.

by Stanley Makumire, Tawanda Zininga, Juha Vahokoski, Inari Kursula, Addmore Shonhai
Published 2020-01-01

Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein.

by Tawanda Zininga, Ikechukwu Achilonu, Heinrich Hoppe, Earl Prinsloo, Heini W Dirr, Addmore Shonhai
Published 2015-01-01

Use of a Chimeric Hsp70 to Enhance the Quality of Recombinant Plasmodium falciparum S-Adenosylmethionine Decarboxylase Protein Produced in Escherichia coli.

by Xolani Henry Makhoba, Adélle Burger, Dina Coertzen, Tawanda Zininga, Lyn-Marie Birkholtz, Addmore Shonhai
Published 2016-01-01

Comparative Characterization of <i>Plasmodium falciparum</i> Hsp70-1 Relative to <i>E. coli</i> DnaK Reveals the Functional Specificity of the Parasite Chaperone

by Charity Mekgwa Lebepe, Pearl Rutendo Matambanadzo, Xolani Henry Makhoba, Ikechukwu Achilonu, Tawanda Zininga, Addmore Shonhai
Published 2020-06-01

(−)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners

by Tawanda Zininga, Lebogang Ramatsui, Pertunia Bveledzani Makhado, Stanley Makumire, Ikechukwu Achilinou, Heinrich Hoppe, Heini Dirr, Addmore Shonhai
Published 2017-12-01

Mutation of GGMP Repeat Segments of <i>Plasmodium falciparum</i> Hsp70-1 Compromises Chaperone Function and Hop Co-Chaperone Binding

by Stanley Makumire, Tendamudzimu Harmfree Dongola, Graham Chakafana, Lufuno Tshikonwane, Cecilia Tshikani Chauke, Tarushai Maharaj, Tawanda Zininga, Addmore Shonhai
Published 2021-02-01

Extracts Obtained from Pterocarpus angolensis DC and Ziziphus mucronata Exhibit Antiplasmodial Activity and Inhibit Heat Shock Protein 70 (Hsp70) Function

by Tawanda Zininga, Chinedu P. Anokwuru, Muendi T. Sigidi, Milingoni P. Tshisikhawe, Isaiah I. D. Ramaite, Afsatou N. Traoré, Heinrich Hoppe, Addmore Shonhai, Natasha Potgieter
Published 2017-07-01

Plasmodium falciparum Hop (PfHop) Interacts with the Hsp70 Chaperone in a Nucleotide-Dependent Fashion and Exhibits Ligand Selectivity.

by Tawanda Zininga, Stanely Makumire, Grace Wairimu Gitau, James M Njunge, Ofentse Jacob Pooe, Hanna Klimek, Robina Scheurr, Hartmann Raifer, Earl Prinsloo, Jude M Przyborski, Heinrich Hoppe, Addmore Shonhai
Published 2015-01-01

Heat Shock Proteins: Potential Modulators and Candidate Biomarkers of Peripartum Cardiomyopathy

by Graham Chakafana, Graham Chakafana, Timothy F. Spracklen, Timothy F. Spracklen, Stephen Kamuli, Stephen Kamuli, Tawanda Zininga, Addmore Shonhai, Ntobeko A. B. Ntusi, Ntobeko A. B. Ntusi, Ntobeko A. B. Ntusi, Karen Sliwa, Karen Sliwa
Published 2021-06-01