Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase

by Kei Kudo, Takehiro Nishimura, Ikuko Kozone, Junko Hashimoto, Noritaka Kagaya, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya
Published 2021-05-01

In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

by Kei Kudo, Takuya Hashimoto, Junko Hashimoto, Ikuko Kozone, Noritaka Kagaya, Reiko Ueoka, Takehiro Nishimura, Mamoru Komatsu, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya
Published 2020-08-01