Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease

by Shoko Hashimoto, Takaomi C. Saido
Published 2018-04-01

Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains

by Md Golam Sharoar, Sarah Palko, Yingying Ge, Takaomi C. Saido, Riqiang Yan
Published 2021-07-01

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease

by Yasufumi Sakakibara, Michiko Sekiya, Takashi Saito, Takaomi C. Saido, Koichi M. Iijima
Published 2019-03-01

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

by Yasufumi Sakakibara, Michiko Sekiya, Takashi Saito, Takaomi C. Saido, Koichi M. Iijima
Published 2018-07-01

Distinct functional consequences of ECEL1/DINE missense mutations in the pathogenesis of congenital contracture disorders

by Kenichi Nagata, Mika Takahashi, Sumiko Kiryu-Seo, Hiroshi Kiyama, Takaomi C. Saido
Published 2017-11-01

Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in

by Marius Chiasseu, Arman Fesharaki-Zadeh, Takashi Saito, Takaomi C. Saido, Stephen M. Strittmatter
Published 2020-11-01

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

by Junjun Ni, Zhou Wu, Jie Meng, Takashi Saito, Takaomi C. Saido, Hong Qing, Hiroshi Nakanishi
Published 2019-08-01

Early identification of Alzheimer's disease in mouse models: Application of deep neural network algorithm to cognitive behavioral parameters

by Stephanie Sutoko, Akira Masuda, Akihiko Kandori, Hiroki Sasaguri, Takashi Saito, Takaomi C. Saido, Tsukasa Funane
Published 2021-03-01

Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification

by Hideko Kokubo, Rakez Kayed, Charles G. Glabe, Matthias Staufenbiel, Takaomi C. Saido, Nobuhisa Iwata, Haruyasu Yamaguchi
Published 2009-01-01

Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD

by Wei Wang, Daisuke Tanokashira, Yusuke Fukui, Megumi Maruyama, Chiemi Kuroiwa, Takashi Saito, Takaomi C. Saido, Akiko Taguchi
Published 2019-08-01

Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology

by Kenichi Nagata, Mika Takahashi, Yukio Matsuba, Fumi Okuyama-Uchimura, Kaori Sato, Shoko Hashimoto, Takashi Saito, Takaomi C. Saido
Published 2018-05-01

T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.

by Shuo Wang, Yasushi Yabuki, Kazuya Matsuo, Jing Xu, Hisanao Izumi, Kenji Sakimura, Takashi Saito, Takaomi C Saido, Kohji Fukunaga
Published 2018-01-01

Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer’s Disease-Related Pathological Progression in the Hippocampus of AppNL-G-F/NL-G-F Mice

by Nobuko Hongo, Yusaku Takamura, Hiroshi Nishimaru, Jumpei Matsumoto, Kazuyuki Tobe, Takashi Saito, Takashi Saito, Takaomi C. Saido, Hisao Nishijo
Published 2020-03-01

Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours

by Eleftheria Pervolaraki, Stephen P. Hall, Denise Foresteire, Takashi Saito, Takaomi C. Saido, Miles A. Whittington, Colin Lever, James Dachtler
Published 2019-09-01

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.

by Hansen Wang, Declan Williams, Jennifer Griffin, Takashi Saito, Takaomi C Saido, Paul E Fraser, Ekaterina Rogaeva, Gerold Schmitt-Ulms
Published 2017-01-01

Correction: T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.

by Shuo Wang, Yasushi Yabuki, Kazuya Matsuo, Jing Xu, Hisanao Izumi, Kenji Sakimura, Takashi Saito, Takaomi C Saido, Kohji Fukunaga
Published 2019-01-01

Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease

by Yoshihide Nakamura, Takeshi Yamamoto, Xiaojuan Xu, Shigeki Kobayashi, Shinji Tanaka, Masaki Tamitani, Takashi Saito, Takaomi C. Saido, Masafumi Yano
Published 2021-03-01

Tau binding protein CAPON induces tau aggregation and neurodegeneration

by Shoko Hashimoto, Yukio Matsuba, Naoko Kamano, Naomi Mihira, Naruhiko Sahara, Jiro Takano, Shin-ichi Muramatsu, Takaomi C. Saido, Takashi Saito
Published 2019-06-01

Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration

by Shoko Hashimoto, Yukio Matsuba, Naoko Kamano, Naomi Mihira, Naruhiko Sahara, Jiro Takano, Shin-ichi Muramatsu, Takaomi C. Saido, Takashi Saito
Published 2019-07-01

Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

by Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu
Published 2021-04-01