Remodelage génomique des sarcomes pléomorphes : caractérisation transcriptomique et agressivité tumorale

by Lesluyes, Tom
Published 2019

The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms

by Tom Lesluyes, Lucile Delespaul, Jean-Michel Coindre, Frédéric Chibon
Published 2017-07-01

An integrative analysis of the age-associated multi-omic landscape across cancers

by Kasit Chatsirisupachai, Tom Lesluyes, Luminita Paraoan, Peter Van Loo, João Pedro de Magalhães
Published 2021-04-01

Recurrent DMD Deletions Highlight Specific Role of Dp71 Isoform in Soft-Tissue Sarcomas

by Olivier Mauduit, Vanessa Delcroix, Tom Lesluyes, Gaëlle Pérot, Pauline Lagarde, Lydia Lartigue, Jean-Yves Blay, Frédéric Chibon
Published 2019-07-01

Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with <i>DMD</i> Deletion

by Candice Merle, Noémie Thébault, Sophie LeGuellec, Jessica Baud, Gaëlle Pérot, Tom Lesluyes, Lucile Delespaul, Lydia Lartigue, Frédéric Chibon
Published 2020-05-01

Cell–cell fusion of mesenchymal cells with distinct differentiations triggers genomic and transcriptomic remodelling toward tumour aggressiveness

by Lucile Delespaul, Caroline Gélabert, Tom Lesluyes, Sophie Le Guellec, Gaëlle Pérot, Laura Leroy, Jessica Baud, Candice Merle, Lydia Lartigue, Frédéric Chibon
Published 2020-12-01

The Role of the Anti-Aging Protein Klotho in IGF-1 Signaling and Reticular Calcium Leak: Impact on the Chemosensitivity of Dedifferentiated Liposarcomas

by Vanessa Delcroix, Olivier Mauduit, Nolwenn Tessier, Anaïs Montillaud, Tom Lesluyes, Thomas Ducret, Frédéric Chibon, Fabien Van Coppenolle, Sylvie Ducreux, Pierre Vacher
Published 2018-11-01

Value of peri-operative chemotherapy in patients with CINSARC high-risk localized grade 1 or 2 soft tissue sarcoma: study protocol of the target selection phase III CHIC-STS trial

by Thomas Filleron, Sophie Le Guellec, Christine Chevreau, Bastien Cabarrou, Tom Lesluyes, Sabrina Lodin, Angélique Massoubre, Muriel Mounier, Muriel Poublanc, Frédéric Chibon, Thibaud Valentin
Published 2020-07-01

Heterogeneous Mechanisms of Secondary Resistance and Clonal Selection in Sarcoma during Treatment with Nutlin.

by Audrey Laroche, Kevin Tran-Cong, Vanessa Chaire, Pauline Lagarde, Isabelle Hostein, Jean-Michel Coindre, Frederic Chibon, Agnes Neuville, Tom Lesluyes, Carlo Lucchesi, Antoine Italiano
Published 2015-01-01

RCBTB1 Deletion Is Associated with Metastatic Outcome and Contributes to Docetaxel Resistance in Nontranslocation-Related Pleomorphic Sarcomas

by Olivier Mauduit, Céline Brulard, Tom Lesluyes, Vanessa Delcroix, Gaëlle Pérot, Nina Choublier, Mickael Michaud, Jessica Baud, Pauline Lagarde, Alain Aurias, Jean-Michel Coindre, Lydia Lartigue, Jean-Yves Blay, Frédéric Chibon
Published 2019-01-01

ATRX Alteration Contributes to Tumor Growth and Immune Escape in Pleomorphic Sarcomas

by Lucie Darmusey, Gaëlle Pérot, Noémie Thébault, Sophie Le Guellec, Nelly Desplat, Laëtitia Gaston, Lucile Delespaul, Tom Lesluyes, Elodie Darbo, Anne Gomez-Brouchet, Elodie Richard, Jessica Baud, Laura Leroy, Jean-Michel Coindre, Jean-Yves Blay, Frédéric Chibon
Published 2021-04-01

Specific immune landscapes and immune checkpoint expressions in histotypes and molecular subtypes of sarcoma

by A. Dufresne, T. Lesluyes, C. Ménétrier-Caux, M. Brahmi, E. Darbo, M. Toulmonde, A. Italiano, O. Mir, A. Le Cesne, S. Le Guellec, T. Valentin, C. Chevreau, S. Bonvalot, Y.M. Robin, J-M Coindre, C. Caux, J.Y. Blay, F. Chibon
Published 2020-01-01