A Trace Amount of Galactose, a Major Component of Milk Sugar, Allows Maturation of Glycoproteins during Sugar Starvation

by Norio Sasaoka, Hiromi Imamura, Akira Kakizuka
Published 2018-12-01

Mdm20 stimulates polyQ aggregation via inhibiting autophagy through Akt-Ser473 phosphorylation.

by Kunihiko Yasuda, Kyoji Ohyama, Kazuko Onga, Akira Kakizuka, Nozomu Mori
Published 2013-01-01

Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance

by Xiang Nie, Shiho Kitaoka, Masakazu Shinohara, Akira Kakizuka, Shuh Narumiya, Tomoyuki Furuyashiki
Published 2019-11-01

Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model

by Tomoko Hasegawa, Hanako O. Ikeda, Sachiko Iwai, Norio Sasaoka, Akira Kakizuka, Akitaka Tsujikawa
Published 2020-12-01

Long-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in mice.

by Norio Sasaoka, Megumi Sakamoto, Shoko Kanemori, Michiru Kan, Chihiro Tsukano, Yoshiji Takemoto, Akira Kakizuka
Published 2014-01-01

KUS121 attenuates the progression of monosodium iodoacetate-induced osteoarthritis in rats

by Sachiko Iwai, Hanako O. Ikeda, Hisashi Mera, Kohei Nishitani, Motoo Saito, Akitaka Tsujikawa, Akira Kakizuka
Published 2021-08-01

VCP Is an integral component of a novel feedback mechanism that controls intracellular localization of catalase and H2O2 Levels.

by Katsuhiro Murakami, Yuzuru Ichinohe, Masaaki Koike, Norio Sasaoka, Shun-ichiro Iemura, Tohru Natsume, Akira Kakizuka
Published 2013-01-01

Exploring rare cellular activity in more than one million cells by a transscale scope

by T. Ichimura, T. Kakizuka, K. Horikawa, K. Seiriki, A. Kasai, H. Hashimoto, K. Fujita, T. M. Watanabe, T. Nagai
Published 2021-08-01

ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease

by Masaki Nakano, Hiromi Imamura, Norio Sasaoka, Masamichi Yamamoto, Norihito Uemura, Toshiyuki Shudo, Tomohiro Fuchigami, Ryosuke Takahashi, Akira Kakizuka
Published 2017-08-01

Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

by Hiromi Imamura, Shuichiro Sakamoto, Tomoki Yoshida, Yusuke Matsui, Silvia Penuela, Dale W Laird, Shin Mizukami, Kazuya Kikuchi, Akira Kakizuka
Published 2020-10-01

In vitro modeling of paraxial mesodermal progenitors derived from induced pluripotent stem cells.

by Hidetoshi Sakurai, Yasuko Sakaguchi, Emi Shoji, Tokiko Nishino, Izumi Maki, Hiroshi Sakai, Kazunori Hanaoka, Akira Kakizuka, Atsuko Sehara-Fujisawa
Published 2012-01-01

Corrigendum to “Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma” [Heliyon 4(2) (March 2018) e00544]

by Tomoko Hasegawa, Hanako Ohashi Ikeda, Sachiko Iwai, Yuki Muraoka, Tatsuaki Tsuruyama, Keiko Okamoto-Furuta, Haruyasu Kohda, Akira Kakizuka, Nagahisa Yoshimura
Published 2018-08-01

Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma

by Tomoko Hasegawa, Hanako Ohashi Ikeda, Sachiko Iwai, Yuki Muraoka, Tatsuaki Tsuruyama, Keiko Okamoto-Furuta, Haruyasu Kohda, Akira Kakizuka, Nagahisa Yoshimura
Published 2018-02-01

A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs

by Yumi Konagaya, Kenta Terai, Yusuke Hirao, Kanako Takakura, Masamichi Imajo, Yuji Kamioka, Norio Sasaoka, Akira Kakizuka, Kenta Sumiyama, Tomoichiro Asano, Michiyuki Matsuda
Published 2017-11-01

Neuroprotective effects of VCP modulators in mouse models of glaucoma

by Noriko Nakano, Hanako Ohashi Ikeda, Tomoko Hasegawa, Yuki Muraoka, Sachiko Iwai, Tatsuaki Tsuruyama, Masaki Nakano, Tomohiro Fuchigami, Toshiyuki Shudo, Akira Kakizuka, Nagahisa Yoshimura
Published 2016-04-01

Real-time imaging of rabbit retina with retinal degeneration by using spectral-domain optical coherence tomography.

by Yuki Muraoka, Hanako Ohashi Ikeda, Noriko Nakano, Masanori Hangai, Yoshinobu Toda, Keiko Okamoto-Furuta, Haruyasu Kohda, Mineo Kondo, Hiroko Terasaki, Akira Kakizuka, Nagahisa Yoshimura
Published 2012-01-01

Safety and effectiveness of a novel neuroprotectant, KUS121, in patients with non-arteritic central retinal artery occlusion: An open-label, non-randomized, first-in-humans, phase...

by Hanako Ohashi Ikeda, Yuki Muraoka, Masayuki Hata, Eriko Sumi, Takafumi Ikeda, Takayuki Nakagawa, Hiroyasu Abe, Harue Tada, Satoshi Morita, Akira Kakizuka, Nagahisa Yoshimura, Akitaka Tsujikawa
Published 2020-01-01

KUS121, an ATP regulator, mitigates chorioretinal pathologies in animal models of age-related macular degeneration

by Yuki Muraoka, Yuto Iida, Hanako O. Ikeda, Sachiko Iwai, Masayuki Hata, Takeshi Iwata, Mao Nakayama, Nobuhiro Shimozawa, Yuko Katakai, Akira Kakizuka, Nagahisa Yoshimura, Akitaka Tsujikawa
Published 2018-05-01

Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL

by An-Hsun Chou, Tu-Hsueh Yeh, Yu-Li Kuo, Yu-Cheng Kao, Mei-Jie Jou, Chia-Yu Hsu, Shu-Ru Tsai, Akira Kakizuka, Hung-Li Wang
Published 2006-02-01

Author Correction: A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis

by Motoo Saito, Kohei Nishitani, Hanako O. Ikeda, Shigeo Yoshida, Sachiko Iwai, Xiang Ji, Akihiro Nakahata, Akira Ito, Shinichiro Nakamura, Shinichi Kuriyama, Hiroyuki Yoshitomi, Koichi Murata, Tomoki Aoyama, Hiromu Ito, Hiroshi Kuroki, Akira Kakizuka, Shuichi Matsuda
Published 2021-03-01