Significance of Antigen and Epitope Specificity in Tuberculosis

by Juraj eIvanyi, Tom H.M. Ottenhoff
Published 2014-10-01

Vaccines against tuberculosis: where are we and where do we need to go?

by Tom H M Ottenhoff, Stefan H E Kaufmann
Published 2012-01-01

B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis

by Willemijn F. Rijnink, Tom H.M. Ottenhoff, Simone A. Joosten
Published 2021-02-01

Regulatory T-cells at the interface between human host and pathogens in infectious diseases and vaccination.

by Mardi C. Boer, Simone A. Joosten, Tom H.M. Ottenhoff
Published 2015-05-01

Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

by Simone A. Joosten, Lucy C. Sullivan, Tom H. M. Ottenhoff
Published 2016-01-01

A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB pathogenesis.

by Simone A Joosten, Helen A Fletcher, Tom H M Ottenhoff
Published 2013-01-01

Tuberculosis biomarkers: from diagnosis to protection

by Delia Goletti, Elisa Petruccioli, Simone A. Joosten, Tom H.M. Ottenhoff
Published 2016-06-01

CD8+ regulatory T cells, and not CD4+ T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells.

by Mardi C Boer, Krista E van Meijgaarden, Simone A Joosten, Tom H M Ottenhoff
Published 2014-01-01

IgA and IgG against Mycobacterium tuberculosis Rv2031 discriminate between pulmonary tuberculosis patients, Mycobacterium tuberculosis-infected and non-infected individuals.

by Fekadu Abebe, Mulugeta Belay, Mengistu Legesse, Franken K L M C, Tom H M Ottenhoff
Published 2018-01-01

Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like Phenotype

by Nadia Caccamo, Nadia Caccamo, Simone A. Joosten, Tom H. M. Ottenhoff, Francesco Dieli, Francesco Dieli
Published 2018-12-01

Potential of DosR and Rpf antigens from Mycobacterium tuberculosis to discriminate between latent and active tuberculosis in a tuberculosis endemic population of Medellin Colombia

by Leonar Arroyo, Diana Marín, Kees L. M. C. Franken, Tom H. M. Ottenhoff, Luis F. Barrera
Published 2018-01-01

Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction.

by Frank Vrieling, Louis Wilson, Patrick C N Rensen, Gerhard Walzl, Tom H M Ottenhoff, Simone A Joosten
Published 2019-04-01

Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represen...

by Krista E van Meijgaarden, Mariëlle C Haks, Nadia Caccamo, Francesco Dieli, Tom H M Ottenhoff, Simone A Joosten
Published 2015-03-01

A Systematic Review on Novel Mycobacterium tuberculosis Antigens and Their Discriminatory Potential for the Diagnosis of Latent and Active Tuberculosis

by Noëmi R. Meier, Noëmi R. Meier, Marc Jacobsen, Tom H. M. Ottenhoff, Nicole Ritz, Nicole Ritz, Nicole Ritz
Published 2018-11-01

Impaired Immune Response to Primary but Not to Booster Vaccination Against Hepatitis B in Older Adults

by Birgit Weinberger, Mariëlle C. Haks, Roelof A. de Paus, Tom H. M. Ottenhoff, Tanja Bauer, Beatrix Grubeck-Loebenstein
Published 2018-05-01

Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile

by Frank Vrieling, Katharina Ronacher, Léanie Kleynhans, Erik van den Akker, Gerhard Walzl, Tom H.M. Ottenhoff, Simone A. Joosten
Published 2018-06-01

INNOVATIVE STRATEGIES TO IDENTIFY M. TUBERCULOSIS ANTIGENS AND EPITOPES USING GENOME-WIDE ANALYSES

by Annemieke eGeluk, Krista E van Meijgaarden, Simone A Joosten, Susanna eCommandeur, Susanna eCommandeur, Tom H.M. Ottenhoff
Published 2014-06-01

MHC Ib molecule Qa-1 presents Mycobacterium tuberculosis peptide antigens to CD8+ T cells and contributes to protection against infection.

by Yao Bian, Shaobin Shang, Sarah Siddiqui, Jie Zhao, Simone A Joosten, Tom H M Ottenhoff, Harvey Cantor, Chyung-Ru Wang
Published 2017-05-01

Pro- and anti-inflammatory cytokines against Rv2031 are elevated during latent tuberculosis: a study in cohorts of tuberculosis patients, household contacts and community controls...

by Mulugeta Belay, Mengistu Legesse, Adane Mihret, Yonas Bekele, Tom H M Ottenhoff, Kees L M C Franken, Gunnar Bjune, Fekadu Abebe
Published 2015-01-01

Gene expression profiles classifying clinical stages of tuberculosis and monitoring treatment responses in Ethiopian HIV-negative and HIV-positive cohorts.

by Gebremedhin Gebremicael, Desta Kassa, Yodit Alemayehu, Atsbeha Gebreegziaxier, Yonas Kassahun, Debbie van Baarle, Tom H M Ottenhoff, Jacqueline M Cliff, Mariëlle C Haks
Published 2019-01-01