APP-Mediated Signaling Prevents Memory Decline in Alzheimer’s Disease Mouse Model

by Carole Deyts, Mary Clutter, Nicholas Pierce, Paramita Chakrabarty, Thomas B. Ladd, Anna Goddi, Awilda M. Rosario, Pedro Cruz, Kulandaivelu Vetrivel, Steven L. Wagner, Gopal Thinakaran, Todd E. Golde, Angèle T. Parent
Published 2019-04-01

A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.

by April M Weissmiller, Orlangie Natera-Naranjo, Sol M Reyna, Matthew L Pearn, Xiaobei Zhao, Phuong Nguyen, Soan Cheng, Lawrence S B Goldstein, Rudolph E Tanzi, Steven L Wagner, William C Mobley, Chengbiao Wu
Published 2015-01-01

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1

by Frank Raven, Joseph F. Ward, Katarzyna M. Zoltowska, Yu Wan, Enjana Bylykbashi, Sean J. Miller, Xunuo Shen, Se Hoon Choi, Kevin D. Rynearson, Oksana Berezovska, Steven L. Wagner, Rudolph E. Tanzi, Can Zhang
Published 2017-10-01

Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

by Sang Su Kwak, Kevin J. Washicosky, Emma Brand, Djuna von Maydell, Jenna Aronson, Susan Kim, Diane E. Capen, Murat Cetinbas, Ruslan Sadreyev, Shen Ning, Enjana Bylykbashi, Weiming Xia, Steven L. Wagner, Se Hoon Choi, Rudolph E. Tanzi, Doo Yeon Kim
Published 2020-03-01