Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

by Davide Normanno, Aurélie Négrel, Abinadabe J de Melo, Stéphane Betzi, Katheryn Meek, Mauro Modesti
Published 2017-05-01

Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain.

by Céline Contesto-Richefeu, Nicolas Tarbouriech, Xavier Brazzolotto, Stéphane Betzi, Xavier Morelli, Wim P Burmeister, Frédéric Iseni
Published 2014-03-01

Stability of the Human Hsp90-p50Cdc37 Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2

by Sanne H. Olesen, Donna J. Ingles, Jin-Yi Zhu, Mathew P. Martin, Stephane Betzi, Gunda I. Georg, Joseph S. Tash, Ernst Schönbrunn
Published 2015-01-01

Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer.

by Melissa Birol, Radoslav Ivanov Enchev, André Padilla, Florian Stengel, Ruedi Aebersold, Stéphane Betzi, Yinshan Yang, François Hoh, Matthias Peter, Christian Dumas, Aude Echalier
Published 2014-01-01

Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments.

by Ylva Ivarsson, Anna Maria Wawrzyniak, Rudra Kashyap, Jolanta Polanowska, Stéphane Betzi, Frédérique Lembo, Elke Vermeiren, Driss Chiheb, Nicolas Lenfant, Xavier Morelli, Jean-Paul Borg, Jérôme Reboul, Pascale Zimmermann
Published 2013-01-01

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology

by Kahina Hammam, Magali Saez-Ayala, Etienne Rebuffet, Laurent Gros, Sophie Lopez, Berengere Hajem, Martine Humbert, Emilie Baudelet, Stephane Audebert, Stephane Betzi, Adrien Lugari, Sebastien Combes, Sebastien Letard, Nathalie Casteran, Colin Mansfield, Alain Moussy, Paulo De Sepulveda, Xavier Morelli, Patrice Dubreuil
Published 2017-11-01

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.

by Amandine Cartier-Michaud, Anne-Laure Bailly, Stéphane Betzi, Xiaoli Shi, Jean-Claude Lissitzky, Ana Zarubica, Arnauld Sergé, Philippe Roche, Adrien Lugari, Véronique Hamon, Florence Bardin, Carine Derviaux, Frédérique Lembo, Stéphane Audebert, Sylvie Marchetto, Bénédicte Durand, Jean-Paul Borg, Ning Shi, Xavier Morelli, Michel Aurrand-Lions
Published 2017-06-01