Stanford V

Stanford V (usually spoken as ''Stanford Five''), is a chemotherapy regimen (with accompanying Radiation therapy) intended as a first-line treatment for Hodgkin lymphoma. The regimen was developed in 1988, with the objective of maintaining a high remission rate while reducing the incidence of acute and long term toxicity, pulmonary damage, and sterility observed in alternative treatment regimens such as ABVD. The chemical agents used are: * A mustard derivative such as cyclophosphamide, chlormethine or ifosfamide * Doxorubicin, an anti-tumor antibiotic * Vinblastine, an alkaloid cell toxin * Vincristine, another alkaloid cell toxin * Bleomycin, another anti-tumor antibiotic * Etoposide, a DNA toxin * Prednisone, a corticosteroid

Drug Regimen {| class="wikitable" |- ! Drug !! Dose !! Mode !! Days |- | Doxorubicin || 25 mg/m² || IV || Days 1 and 15 |- | Vinblastine || 6 mg/m² || IV || Days 1 and 15 |- | Chlormethine || 6 mg/m² || IV || Day 1 |- | Vincristine || 1.4 mg/m² (max 2 mg) || IV || Days 8 and 22 |- | Bleomycin || 5 units/m² || IV || Days 8 and 22 |- | Etoposide || 60 mg/m² || IV || Days 15, 16 |- | Prednisone || 40 mg/m² || PO || Q2D |}

The chemotherapy part of Stanford V treatment can last anywhere from 8 to 12 weeks, depending on the staging of the disease. In many cases, this is followed by radiation therapy for anywhere from 2 to 6 weeks to the affected areas of the body.

Stanford V is a more rigorously administered form of chemotherapy, with treatments roughly twice as fast as those of other Hodgkin lymphoma treatments. However, in a randomized controlled study, Stanford V was inferior to ABVD. This study has been criticized for not adhering to the proper Stanford V protocol. Specifically, the radiation therapy component following chemotherapy was not properly administered in the Italian study. A retrospective study from the Memorial Sloan-Kettering Cancer Center displayed results similar to the Stanford Cancer Center's own experience. The study concluded that, "Stanford V with appropriate radiotherapy is a highly effective regimen for locally extensive and advanced HL." Provided by Wikipedia