Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma

by Soumya R. Mohapatra, Ahmed Sadik, Ahmed Sadik, Lars-Oliver Tykocinski, Jørn Dietze, Gernot Poschet, Ines Heiland, Christiane A. Opitz, Christiane A. Opitz
Published 2019-12-01

Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation

by Isabell Adam, Dyah L. Dewi, Joram Mooiweer, Ahmed Sadik, Soumya R. Mohapatra, Bianca Berdel, Melanie Keil, Jana K. Sonner, Kathrin Thedieck, Adam J. Rose, Michael Platten, Ines Heiland, Saskia Trump, Christiane A. Opitz
Published 2018-12-01

Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production

by Soumya R. Mohapatra, Ahmed Sadik, Suraj Sharma, Gernot Poschet, Hagen M. Gegner, Tobias V. Lanz, Tobias V. Lanz, Tobias V. Lanz, Philippe Lucarelli, Ursula Klingmüller, Ursula Klingmüller, Michael Platten, Michael Platten, Ines Heiland, Christiane A. Opitz, Christiane A. Opitz
Published 2021-02-01

Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ

by Takumi Kudo, Takumi Kudo, Takumi Kudo, Mirja T. Prentzell, Soumya R. Mohapatra, Felix Sahm, Felix Sahm, Zhongliang Zhao, Ingrid Grummt, Wolfgang Wick, Wolfgang Wick, Christiane A. Opitz, Christiane A. Opitz, Michael Platten, Michael Platten, Edward W. Green, Edward W. Green
Published 2020-05-01

Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer

by Dyah L. Dewi, Soumya R. Mohapatra, Saioa Blanco Cabañes, Isabell Adam, Luis F. Somarribas Patterson, Bianca Berdel, Masroor Kahloon, Loreen Thürmann, Stefanie Loth, Katharina Heilmann, Dieter Weichenhan, Oliver Mücke, Ines Heiland, Pauline Wimberger, Jan Dominik Kuhlmann, Karl-Heinz Kellner, Sarah Schott, Christoph Plass, Michael Platten, Clarissa Gerhäuser, Saskia Trump, Christiane A. Opitz
Published 2017-02-01

Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology

by Jana K. Sonner, Melanie Keil, Maren Falk-Paulsen, Neha Mishra, Ateequr Rehman, Magdalena Kramer, Katrin Deumelandt, Julian Röwe, Khwab Sanghvi, Lara Wolf, Anna von Landenberg, Hendrik Wolff, Richa Bharti, Iris Oezen, Tobias V. Lanz, Florian Wanke, Yilang Tang, Ines Brandao, Soumya R. Mohapatra, Lisa Epping, Alexandra Grill, Ralph Röth, Beate Niesler, Sven G. Meuth, Christiane A. Opitz, Jürgen G. Okun, Christoph Reinhardt, Florian C. Kurschus, Wolfgang Wick, Helge B. Bode, Philip Rosenstiel, Michael Platten
Published 2019-10-01