Stem Cells, Genome Editing, and the Path to Translational Medicine

by Soldner, Frank, Jaenisch, Rudolf
Published 2020

Tracing Dynamic Changes of DNA Methylation at Single-Cell Resolution

by Stelzer, Yonatan, Soldner, Frank, Markoulaki, Styliani, Shivalila, Chikdu Shakti, Jaenisch, Rudolf
Published 2017

Transgene Excision Has No Impact on In Vivo Integration of Human iPS Derived Neural Precursors

by Major, Tamara, Menon, Jayanthi, Auyeung, Gordon, Soldner, Frank, Hockemeyer, Dirk, Jaenisch, Rudolf, Tabar, Viviane
Published 2012

Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells

by Guenther, Matthew G., Frampton, Garrett M., Soldner, Frank, Hockemeyer, Dirk, Mitalipova, Maya, Jaenisch, Rudolf, Young, Richard A.
Published 2015

Human embryonic stem cells with biological and epigenetic to those of mouse ESCs

by Jaenisch, Rudolf, Hanna, Jacob, Cheng, Albert W., Saha, Krishanu, Kim, Jongpil, Lengner, Christopher J., Soldner, Frank, Cassady, John P., Muffat, Julien, Carey, Bryce W.
Published 2011

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

by Dettmer, Ulf, Newman, Andrew J., Soldner, Frank, Luth, Eric S., Kim, Nora C., von Saucken, Victoria E., Sanderson, John B., Jaenisch, Rudolf, Bartels, Tim, Selkoe, Dennis
Published 2015

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

by Soldner, Frank, Hockemeyer, Dirk, Beard, Caroline, Gao, Qing, Bell, George W., Cook, Elizabeth G., Hargus, Gunnar, Blak, Alexandra, Cooper, Oliver, Mitalipova, Maisam, Isacson, Ole, Jaenisch, Rudolf
Published 2015

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

by Soldner, Frank, Stelzer, Yonatan, Abraham, Brian J., Latourelle, Jeanne C., Barrasa, M. Inmaculada, Goldmann, Johanna, Myers, Richard H., Jaenisch, Rudolf, Shivalila, Chikdu Shakti, Young, Richard A.
Published 2017

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

by Jaenisch, Rudolf, Hargus, Gunnar, Cooper, Oliver, Deleidi, Michela, Levy, Adam, Lee, Kristen N., Marlow, Elizabeth, Yow, Alyssa, Soldner, Frank, Hockemeyer, Dirk, Hallett, Penelope J., Osborn, Teresia, Isacson, Ole
Published 2014

Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication

by Flierl, Adrian, Oliveira, Luís M. A., Falomir-Lockhart, Lisandro J., Mak, Sally K., Hesley, Jayne, Soldner, Frank, Arndt-Jovin, Donna J., Jaenisch, Rudolf, Langston, J. William, Jovin, Thomas M., Schüle, Birgitt
Published 2014

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models

by Oh, Chang-Ki, Sultan, Abdullah, Platzer, Joseph, Dolatabadi, Nima, Soldner, Frank, McClatchy, Daniel B., Diedrich, Jolene K., Ambasudhan, Rajesh, Nakamura, Tomohiro, Jaenisch, Rudolf, Lipton, Stuart A., Yates, John R., III
Published 2018

Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs

by Song, Yuelin, van den Berg, Patrick R., Markoulaki, Styliani, Soldner, Frank, Dall'Agnese, Alessandra, Henninger, Jonathan E., Drotar, Jesse, Rosenau, Nicholas, Cohen, Malkiel A., Young, Richard A., Semrau, Stefan, Stelzer, Yonatan, Jaenisch, Rudolf
Published 2020

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

by Chung, Chee Yeun, Khurana, Vikram, Auluck, Pavan K., Tardiff, Daniel F., Mazzulli, Joseph R., Soldner, Frank, Baru, Valeriya, Lou, Yali, Freyzon, Yelena, Cho, Sukhee, Muffat, Julien, Mitalipova, Maisam, Pluth, Michael D., Jui, Nathan T., Schule, Birgitt, Lippard, Stephen J., Tsai, Li-Huei, Krainc, Dimitri, Jaenisch, Rudolf, Lindquist, Susan, Mungenast, Alison, Buchwald, Stephen Leffler
Published 2015

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

by Soldner, Frank, Hockemeyer, Dirk, Gao, Qing, Alagappan, Raaji, Khurana, Vikram, Golbe, Lawrence I, Myers, Richard H., Lindquist, Susan, Guschin, Dmitry, Fong, Lauren K, Vu, B. Joseph, Meng, Xiangdong, Urnov, Fyodor D, Rebar, Edward J, Gregory, Philip D., Zhang, H. Steve, Jaenisch, Rudolf, Laganiere, Josee, Zhang, Lei, Ph. D Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, fl. 2014, Cheng, Albert Wu
Published 2014

Isogenic Human iPSC Parkinson's Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

by Ryan, Scott D, Dolatabadi, Nima, Chan, Shing Fai, Zhang, Xiaofei, Akhtar, Mohd Waseem, Parker, James, Soldner, Frank, Sunico, Carmen R, Nagar, Saumya, Talantova, Maria, Lopez, Kevin, Nutter, Anthony, Shan, Bing, Molokanova, Elena, Zhang, Yaoyang, Han, Xuemei, Nakamura, Tomohiro, Masliah, Eliezer, Yates, John R, Nakanishi, Nobuki, Andreyev, Aleksander Y, Okamoto, Shu-ichi, Jaenisch, Rudolf, Ambasudhan, Rajesh, Lipton, Stuart A, Lee, Brian 1975-
Published 2016

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

by Brennand, Kristen J, Marchetto, M. Carol, Benvenisty, Nissim, Brustle, Oliver, Ebert, Allison, Izpisua Belmonte, Juan Carlos, Kaykas, Ajamete, Lancaster, Madeline A, Livesey, Frederick J, McConnell, Michael J, McKay, Ronald D, Morrow, Eric M, Muotri, Alysson R, Panchision, David M, Rubin, Lee L, Sawa, Akira, Soldner, Frank, Song, Hongjun, Studer, Lorenz, Temple, Sally, Vaccarino, Flora M, Wu, Jun, Vanderhaeghen, Pierre, Gage, Fred H, Jaenisch, Rudolf
Published 2016

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

by Fanning, Saranna, Haque, Aftabul, Imberdis, Thibaut, Baru, Valeriya, Barrasa, M. Inmaculada, Nuber, Silke, Termine, Daniel, Ramalingam, Nagendran, Ho, Gary P.H, Noble, Tallie, Sandoe, Jackson, Lou, Yali, Landgraf, Dirk, Freyzon, Yelena, Newby, Gregory, Soldner, Frank, Terry-Kantor, Elizabeth, Kim, Tae-Eun, Hofbauer, Harald F., Becuwe, Michel, Jaenisch, Rudolf, Pincus, David, Clish, Clary B., Walther, Tobias C., Farese, Robert V., Srinivasan, Supriya, Welte, Michael A., Kohlwein, Sepp D., Dettmer, Ulf, Lindquist, Susan, Selkoe, Dennis
Published 2020