Rationally engineered Cas9 nucleases with improved specificity

by Slaymaker, Ian, Gao, Linyi, Zetsche, Bernd, Scott, David Arthur, Yan, Winston Xia, Zhang, Feng
Published 2016

Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28

by Shmakov, Sergey, Makarova, Kira S., Koonin, Eugene V., Smargon, Aaron Andrew, Cox, David Benjamin Turitz, Pyzocha, Neena, Zheng, Kaijie, Slaymaker, Ian, Gootenberg, Jonathan S, Essletzbichler, Patrick, Zhang, Feng, Abudayyeh, Omar O.
Published 2018

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

by Makarova, Kira S, van der Oost, John, Koonin, Eugene V, Zetsche, Bernd, Gootenberg, Jonathan S, Abudayyeh, Omar Osama, Slaymaker, Ian, Essletzbichler, Patrick, Volz, Sara E., Joung, Julia, Regev, Aviv, Zhang, Feng
Published 2016

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits

by Shetty, Ashwin S., Weisbach, Niels R., Crabtree, Gerald R., Platt, Randall Jeffrey, Zhou, Yang, Slaymaker, Ian, Kim, Jinah, Sharma, Jitendra, Desai, Mitul, Sood, Sabina, Kempton, Hannah R., Feng, Guoping, Zhang, Feng
Published 2017

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

by Slaymaker, Ian, Mesa, Pablo, Kellner, Max J., Kannan, Soumya, Brignole, Edward J, Koob, Jeremy, Feliciano, Patricia Rosa, Stella, Stefano, Abudayyeh, Omar O., Gootenberg, Jonathan S, Strecker, Jonathan, Montoya, Guillermo, Zhang, Feng
Published 2020

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

by Shmakov, S., Makarova, K. S., Semenova, E., Minakhin, L., Severinov, K., Koonin, E. V., Regev, Aviv, Gootenberg, Jonathan S, Konermann, Silvana M, Joung, Julia, Slaymaker, Ian, Cox, David Benjamin Turitz, Lander, Eric Steven, Zhang, Feng, Abudayyeh, Omar O.
Published 2016