Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors.

by Andrea Sottoriva, Louis Vermeulen, Simon Tavaré
Published 2011-05-01

High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers.

by Kimberly D Siegmund, Paul Marjoram, Simon Tavaré, Darryl Shibata
Published 2011-01-01

The stem cell population of the human colon crypt: analysis via methylation patterns.

by Pierre Nicolas, Kyoung-Mee Kim, Darryl Shibata, Simon Tavaré
Published 2007-03-01

Using GFP video to track 3D movement and conditional gene expression in free-moving flies.

by Reza Ardekani, Yichuan Michelle Huang, Prathamesh Sancheti, Ramunas Stanciauskas, Simon Tavaré, John Tower
Published 2012-01-01

Hydrogen peroxide stimulates activity and alters behavior in Drosophila melanogaster.

by Dhruv Grover, Daniel Ford, Christopher Brown, Nicholas Hoe, Aysen Erdem, Simon Tavaré, John Tower
Published 2009-10-01

Calling sample mix-ups in cancer population studies.

by Andy G Lynch, Suet-Feung Chin, Mark J Dunning, Carlos Caldas, Simon Tavaré, Christina Curtis
Published 2012-01-01

The relative timing of mutations in a breast cancer genome.

by Scott Newman, Karen D Howarth, Chris D Greenman, Graham R Bignell, Simon Tavaré, Paul A W Edwards
Published 2013-01-01

Fkh1 and Fkh2 bind multiple chromosomal elements in the S. cerevisiae genome with distinct specificities and cell cycle dynamics.

by A Zachary Ostrow, Tittu Nellimoottil, Simon R V Knott, Catherine A Fox, Simon Tavaré, Oscar M Aparicio
Published 2014-01-01

The mutREAD method detects mutational signatures from low quantities of cancer DNA

by Juliane Perner, Sujath Abbas, Karol Nowicki-Osuch, Ginny Devonshire, Matthew D. Eldridge, Simon Tavaré, Rebecca C. Fitzgerald
Published 2020-06-01

Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes.

by Ben E Housden, Audrey Q Fu, Alena Krejci, Fred Bernard, Bettina Fischer, Simon Tavaré, Steven Russell, Sarah J Bray
Published 2013-01-01

Modifier effects between regulatory and protein-coding variation.

by Antigone S Dimas, Barbara E Stranger, Claude Beazley, Robert D Finn, Catherine E Ingle, Matthew S Forrest, Matthew E Ritchie, Panos Deloukas, Simon Tavaré, Emmanouil T Dermitzakis
Published 2008-10-01

Genome-wide associations of gene expression variation in humans.

by Barbara E Stranger, Matthew S Forrest, Andrew G Clark, Mark J Minichiello, Samuel Deutsch, Robert Lyle, Sarah Hunt, Brenda Kahl, Stylianos E Antonarakis, Simon Tavaré, Panagiotis Deloukas, Emmanouil T Dermitzakis
Published 2005-12-01

Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor.

by Caitlin M Conboy, Christiana Spyrou, Natalie P Thorne, Elizabeth J Wade, Nuno L Barbosa-Morais, Michael D Wilson, Arindam Bhattacharjee, Richard A Young, Simon Tavaré, Jacqueline A Lees, Duncan T Odom
Published 2007-10-01

Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53.

by Kristina Kirschner, Shamith A Samarajiwa, Jonathan M Cairns, Suraj Menon, Pedro A Pérez-Mancera, Kosuke Tomimatsu, Camino Bermejo-Rodriguez, Yoko Ito, Tamir Chandra, Masako Narita, Scott K Lyons, Andy G Lynch, Hiroshi Kimura, Tetsuya Ohbayashi, Simon Tavaré, Masashi Narita
Published 2015-03-01

Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer

by Mohammad Asim, Firas Tarish, Heather I. Zecchini, Kumar Sanjiv, Eleni Gelali, Charles E. Massie, Ajoeb Baridi, Anne Y. Warren, Wanfeng Zhao, Christoph Ogris, Leigh-Anne McDuffus, Patrice Mascalchi, Greg Shaw, Harveer Dev, Karan Wadhwa, Paul Wijnhoven, Josep V. Forment, Scott R. Lyons, Andy G. Lynch, Cormac O’Neill, Vincent R. Zecchini, Paul S. Rennie, Aria Baniahmad, Simon Tavaré, Ian G. Mills, Yaron Galanty, Nicola Crosetto, Niklas Schultz, David Neal, Thomas Helleday
Published 2017-08-01

Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue

by Kevin Litchfield, Stacey Stanislaw, Lavinia Spain, Lisa L. Gallegos, Andrew Rowan, Desiree Schnidrig, Heidi Rosenbaum, Alexandre Harle, Lewis Au, Samantha M. Hill, Zayd Tippu, Jennifer Thomas, Lisa Thompson, Hang Xu, Stuart Horswell, Aoune Barhoumi, Carol Jones, Katherine F. Leith, Daniel L. Burgess, Thomas B.K. Watkins, Emilia Lim, Nicolai J. Birkbak, Philippe Lamy, Iver Nordentoft, Lars Dyrskjøt, Lisa Pickering, Stephen Hazell, Mariam Jamal-Hanjani, James Larkin, Charles Swanton, Nelson R. Alexander, Samra Turajlic, Chris Abbosh, Kai-Keen Shiu, John Bridgewater, Daniel Hochhauser, Martin Forster, Siow-Ming Lee, Tanya Ahmad, Dionysis Papadatos-Pastos, Sam Janes, Peter Van Loo, Katey Enfield, Nicholas McGranahan, Ariana Huebner, Sergio Quezada, Stephan Beck, Peter Parker, Henning Walczak, Tariq Enver, Rob Hynds, Mary Falzon, Ian Proctor, Ron Sinclair, Chi-wah Lok, Zoe Rhodes, David Moore, Teresa Marafioti, Elaine Borg, Miriam Mitchison, Reena Khiroya, Giorgia Trevisan, Peter Ellery, Mark Linch, Sebastian Brandner, Crispin Hiley, Selvaraju Veeriah, Maryam Razaq, Heather Shaw, Gert Attard, Mita Afroza Akther, Cristina Naceur-Lombardelli, Lizi Manzano, Maise Al-Bakir, Simranpreet Summan, Nnenna Kanu, Sophie Ward, Uzma Asghar, Emilia Lim, Faye Gishen, Adrian Tookman, Paddy Stone, Caroline Stirling, Andrew Furness, Kim Edmonds, Nikki Hunter, Sarah Sarker, Sarah Vaughan, Mary Mangwende, Karla Pearce, Lavinia Spain, Scott Shepherd, Haixi Yan, Ben Shum, Eleanor Carlyle, Steve Hazell, Annika Fendler, Fiona Byrne, Nadia Yousaf, Sanjay Popat, Olivia Curtis, Gordon Stamp, Antonia Toncheva, Emma Nye, Aida Murra, Justine Korteweg, Nahid Sheikh, Debra Josephs, Ashish Chandra, James Spicer, Ula Mahadeva, Anna Green, Ruby Stewart, Lara-Rose Iredale, Tina Mackay, Ben Deakin, Debra Enting, Sarah Rudman, Sharmistha Ghosh, Lena Karapagniotou, Elias Pintus, Andrew Tutt, Sarah Howlett, Vasiliki Michalarea, James Brenton, Carlos Caldas, Rebecca Fitzgerald, Merche Jimenez-Linan, Elena Provenzano, Alison Cluroe, Grant Stewart, Colin Watts, Richard Gilbertson, Ultan McDermott, Simon Tavare, Emma Beddowes, Patricia Roxburgh, Andrew Biankin, Anthony Chalmers, Sioban Fraser, Karin Oien, Andrew Kidd, Kevin Blyth, Matt Krebs, Fiona Blackhall, Yvonne Summers, Caroline Dive, Richard Marais, Fabio Gomes, Mat Carter, Jo Dransfield, John Le Quesne, Dean Fennell, Jacqui Shaw, Babu Naidu, Shobhit Baijal, Bruce Tanchel, Gerald Langman, Andrew Robinson, Martin Collard, Peter Cockcroft, Charlotte Ferris, Hollie Bancroft, Amy Kerr, Gary Middleton, Joanne Webb, Salma Kadiri, Peter Colloby, Bernard Olisemeke, Rodelaine Wilson, Ian Tomlinson, Sanjay Jogai, Christian Ottensmeier, David Harrison, Massimo Loda, Adrienne Flanagan, Mairead McKenzie, Allan Hackshaw, Jonathan Ledermann, Abby Sharp, Laura Farrelly, Hayley Bridger
Published 2020-05-01