Understanding anti-tuberculosis drug efficacy: rethinking bacterial populations and how we model them

by Dimitrios Evangelopoulos, Joana Diniz da Fonseca, Simon J. Waddell
Published 2015-03-01

Multi-Omics Technologies Applied to Tuberculosis Drug Discovery

by Aaron Goff, Daire Cantillon, Leticia Muraro Wildner, Simon J Waddell
Published 2020-07-01

Correction: Lu et al. Weighted Gene Co-Expression Network Analysis Identifies Key Modules and Hub Genes Associated with Mycobacterial Infection of Human Macrophages. <i>Antibiotics...

by Lu Lu, Ran-Lei Wei, Sanjib Bhakta, Simon J. Waddell, Ester Boix
Published 2021-06-01

Three-dimensional low shear culture of Mycobacterium bovis BCG induces biofilm formation and antimicrobial drug tolerance

by Daire Cantillon, Justyna Wroblewska, Ian Cooper, Melanie J. Newport, Simon J. Waddell
Published 2021-02-01

Weighted Gene Co-Expression Network Analysis Identifies Key Modules and Hub Genes Associated with Mycobacterial Infection of Human Macrophages

by Lu Lu, RanLei Wei, Sanjib Bhakta, Simon J. Waddell, Ester Boix
Published 2021-01-01

Potassium availability triggers Mycobacterium tuberculosis transition to, and resuscitation from, non-culturable (dormant) states

by Elena G. Salina, Simon J. Waddell, Nadine Hoffmann, Ida Rosenkrands, Philip D. Butcher, Arseny S. Kaprelyants
Published 2014-01-01

A Novel TetR-Like Transcriptional Regulator Is Induced in Acid-Nitrosative Stress and Controls Expression of an Efflux Pump in Mycobacteria

by Filomena Perrone, Barbara De Siena, Lidia Muscariello, Sharon L. Kendall, Simon J. Waddell, Margherita Sacco
Published 2017-10-01

Spontaneously Occurring Small-Colony Variants of Staphylococcus aureus Show Enhanced Clearance by THP-1 Macrophages

by Simon M. Stoneham, Simon M. Stoneham, Daire M. Cantillon, Simon J. Waddell, Martin J. Llewelyn, Martin J. Llewelyn
Published 2020-06-01

Dissecting interferon-induced transcriptional programs in human peripheral blood cells.

by Simon J Waddell, Stephen J Popper, Kathleen H Rubins, Michael J Griffiths, Patrick O Brown, Michael Levin, David A Relman
Published 2010-03-01

Characterization of the Mycobacterial MSMEG-3762/63 Efflux Pump in Mycobacterium smegmatis Drug Efflux

by Barbara De Siena, Nicoletta Campolattano, Gianluca D’Abrosca, Luigi Russo, Daire Cantillon, Rosangela Marasco, Lidia Muscariello, Simon J. Waddell, Margherita Sacco
Published 2020-12-01

Lipid droplets and the transcriptome of Mycobacterium tuberculosis from direct sputa: a literature review

by Daniel Mekonnen, Awoke Derbie, Adane Mihret, Solomon Abebe Yimer, Tone Tønjum, Baye Gelaw, Endalkachew Nibret, Abaineh Munshae, Simon J. Waddell, Abraham Aseffa
Published 2021-10-01

Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages.

by Alice H Li, Simon J Waddell, Jason Hinds, Chad A Malloff, Manjeet Bains, Robert E Hancock, Wan L Lam, Philip D Butcher, Richard W Stokes
Published 2010-06-01

Search for Antimicrobial Activity Among Fifty-Two Natural and Synthetic Compounds Identifies Anthraquinone and Polyacetylene Classes That Inhibit Mycobacterium tuberculosis

by Luiz A. E. Pollo, Erlon F. Martin, Vanessa R. Machado, Daire Cantillon, Leticia Muraro Wildner, Maria Luiza Bazzo, Simon J. Waddell, Maique W. Biavatti, Louis P. Sandjo
Published 2021-01-01

Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages.

by Ludovic Tailleux, Simon J Waddell, Mattia Pelizzola, Alessandra Mortellaro, Michael Withers, Antoine Tanne, Paola Ricciardi Castagnoli, Brigitte Gicquel, Neil G Stoker, Philip D Butcher, Maria Foti, Olivier Neyrolles
Published 2008-01-01

Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum.

by Natalie J Garton, Simon J Waddell, Anna L Sherratt, Su-Min Lee, Rebecca J Smith, Claire Senner, Jason Hinds, Kumar Rajakumar, Richard A Adegbola, Gurdyal S Besra, Philip D Butcher, Michael R Barer
Published 2008-04-01

Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity

by Emma J. Kenyon, Nerissa K. Kirkwood, Siân R. Kitcher, Richard J. Goodyear, Marco Derudas, Daire M. Cantillon, Sarah Baxendale, Antonio de la Vega de León, Virginia N. Mahieu, Richard T. Osgood, Charlotte Donald Wilson, James C. Bull, Simon J. Waddell, Tanya T. Whitfield, Simon E. Ward, Corné J. Kros, Guy P. Richardson
Published 2021-04-01

Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function.

by Cheryl Hemingway, Maurice Berk, Suzanne T Anderson, Victoria J Wright, Shea Hamilton, Hariklia Eleftherohorinou, Myrsini Kaforou, Greg M Goldgof, Katy Hickman, Beate Kampmann, Johan Schoeman, Brian Eley, David Beatty, Sandra Pienaar, Mark P Nicol, Michael J Griffiths, Simon J Waddell, Sandra M Newton, Lachlan J Coin, David A Relman, Giovanni Montana, Michael Levin
Published 2017-01-01