Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis

by Anna R. Poetsch, Simon J. Boulton, Nicholas M. Luscombe
Published 2018-12-01

Caenorhabditis elegans HIM-18/SLX-4 interacts with SLX-1 and XPF-1 and maintains genomic integrity in the germline by processing recombination intermediates.

by Takamune T Saito, Jillian L Youds, Simon J Boulton, Monica P Colaiácovo
Published 2009-11-01

A C-circle assay for detection of alternative lengthening of telomere activity in FFPE tissue

by Aurora I. Idilli, Sandra Segura-Bayona, Timothy P. Lippert, Simon J. Boulton
Published 2021-06-01

Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function

by Mário Špírek, Martin R. G. Taylor, Ondrej Belan, Simon J. Boulton, Lumir Krejci
Published 2021-09-01

Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication

by Roberto Bellelli, Jillian Youds, Valerie Borel, Jennifer Svendsen, Visnja Pavicic-Kaltenbrunner, Simon J. Boulton
Published 2020-05-01

Generation of versatile ss-dsDNA hybrid substrates for single-molecule analysis

by Ondrej Belan, George Moore, Artur Kaczmarczyk, Matthew D. Newton, Roopesh Anand, Simon J. Boulton, David S. Rueda
Published 2021-06-01

RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility

by Aisling Frizzell, Jennifer H.G. Nguyen, Mark I.R. Petalcorin, Katherine D. Turner, Simon J. Boulton, Catherine H. Freudenreich, Robert S. Lahue
Published 2016-08-01

RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility

by Aisling Frizzell, Jennifer H.G. Nguyen, Mark I.R. Petalcorin, Katherine D. Turner, Simon J. Boulton, Catherine H. Freudenreich, Robert S. Lahue
Published 2014-03-01

Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

by Sandra Segura-Bayona, Marina Villamor-Payà, Camille Stephan-Otto Attolini, Lars M. Koenig, Maria Sanchiz-Calvo, Simon J. Boulton, Travis H. Stracker
Published 2020-08-01

Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis.

by Nigel J O'Neil, Julie S Martin, Jillian L Youds, Jordan D Ward, Mark I R Petalcorin, Anne M Rose, Simon J Boulton
Published 2013-01-01

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

by Luka Bacic, Guillaume Gaullier, Anton Sabantsev, Laura C Lehmann, Klaus Brackmann, Despoina Dimakou, Mario Halic, Graeme Hewitt, Simon J Boulton, Sebastian Deindl
Published 2021-09-01

Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

by Tohru Takaki, Marco Montagner, Murielle P. Serres, Maël Le Berre, Matt Russell, Lucy Collinson, Karoly Szuhai, Michael Howell, Simon J. Boulton, Erik Sahai, Mark Petronczki
Published 2017-07-01

Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres

by Timothy P. Lippert, Paulina Marzec, Aurora I. Idilli, Grzegorz Sarek, Aleksandra Vancevska, Mark Bower, Paul J. Farrell, Päivi M. Ojala, Niklas Feldhahn, Simon J. Boulton
Published 2021-01-01

Phosphorylation-Dependent PIH1D1 Interactions Define Substrate Specificity of the R2TP Cochaperone Complex

by Zuzana Hořejší, Lasse Stach, Thomas G. Flower, Dhira Joshi, Helen Flynn, J. Mark Skehel, Nicola J. O’Reilly, Roksana W. Ogrodowicz, Stephen J. Smerdon, Simon J. Boulton
Published 2014-04-01

A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome.

by Bari J Ballew, Vijai Joseph, Saurav De, Grzegorz Sarek, Jean-Baptiste Vannier, Travis Stracker, Kasmintan A Schrader, Trudy N Small, Richard O'Reilly, Chris Manschreck, Megan M Harlan Fleischut, Liying Zhang, John Sullivan, Kelly Stratton, Meredith Yeager, Kevin Jacobs, Neelam Giri, Blanche P Alter, Joseph Boland, Laurie Burdett, Kenneth Offit, Simon J Boulton, Sharon A Savage, John H J Petrini
Published 2013-08-01

Corrigendum: Clinical and Molecular Heterogeneity of RTEL1 Deficiency

by Carsten Speckmann, Carsten Speckmann, Sushree Sangita Sahoo, Sushree Sangita Sahoo, Sushree Sangita Sahoo, Marta Rizzi, Marta Rizzi, Shinsuke Hirabayashi, Axel Karow, Nina Kathrin Serwas, Nina Kathrin Serwas, Marc Hoemberg, Natalja Damatova, Detlev Schindler, Jean-Baptiste Vannier, Simon J. Boulton, Ulrich Pannicke, Gudrun Göhring, Kathrin Thomay, J. J. Verdu-Amoros, Holger Hauch, Wilhelm Woessmann, Gabriele Escherich, Eckart Laack, Liliana Rindle, Maximilian Seidl, Maximilian Seidl, Anne Rensing-Ehl, Ekkehart Lausch, Christine Jandrasits, Brigitte Strahm, Klaus Schwarz, Stephan R. Ehl, Stephan R. Ehl, Charlotte Niemeyer, Charlotte Niemeyer, Charlotte Niemeyer, Kaan Boztug, Kaan Boztug, Kaan Boztug, Kaan Boztug, Marcin W. Wlodarski, Marcin W. Wlodarski, Marcin W. Wlodarski
Published 2017-10-01

Clinical and Molecular Heterogeneity of RTEL1 Deficiency

by Marcin W. Wlodarski, Marcin W. Wlodarski, Marcin W. Wlodarski, Carsten Speckmann, Carsten Speckmann, Sushree Sangita Sahoo, Sushree Sangita Sahoo, Marta Rizzi, Marta Rizzi, Shinsuke Hirabayashi, Axel Karow, Nina Kathrin Serwas, Nina Kathrin Serwas, Marc Hoemberg, Natalja Damatova, Detlev Schindler, Jean-Baptiste Vannier, Simon J. Boulton, Ulrich Pannicke, Gudrun Göhring, Kathrin Thomay, J. J. Verdu-Amoros, Holger Hauch, Wilhelm Woessmann, Gabriele Escherich, Eckart Laack, Liliana Rindle, Maximilian Seidl, Maximilian Seidl, Anne Rensing-Ehl, Ekkehart Lausch, Christine Jandrasits, Brigitte Strahm, Klaus Schwarz, Stephan R. Ehl, Stephan R. Ehl, Charlotte Niemeyer, Charlotte Niemeyer, Charlotte Niemeyer, Kaan Boztug, Kaan Boztug, Kaan Boztug, Kaan Boztug
Published 2017-05-01

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

by Diana Zatreanu, Helen M. R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert A. Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall M. B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M. Badder, Daniela Novo, Eleanor G. Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Wojciech Krajewski, Ellen MacDonald, Hollie McCarron, Leon Pang, Chris Pedder, Laurent Rigoreau, Martin Swarbrick, Ed Wheatley, Simon Willis, Ai Ching Wong, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Stephen J. Pettitt, Graeme C. M. Smith, Christopher J. Lord
Published 2021-06-01