Single Domain Human Immunoglobulin Fold-Based Biomolecules

by Simon E. Hufton
Published 2000-01-01

Cross-Neutralising Nanobodies Bind to a Conserved Pocket in the Hemagglutinin Stem Region Identified Using Yeast Display and Deep Mutational Scanning.

by Tiziano Gaiotto, Simon E Hufton
Published 2016-01-01

Broad Reactivity Single Domain Antibodies against Influenza Virus and Their Applications to Vaccine Potency Testing and Immunotherapy

by Andrew Tung Yep, Yasu Takeuchi, Othmar G Engelhardt, Simon E Hufton
Published 2021-03-01

The breadth of cross sub-type neutralisation activity of a single domain antibody to influenza hemagglutinin can be increased by antibody valency.

by Simon E Hufton, Paul Risley, Christina R Ball, Diane Major, Othmar G Engelhardt, Stephen Poole
Published 2014-01-01

Nanobodies mapped to cross-reactive and divergent epitopes on A(H7N9) influenza hemagglutinin using yeast display

by Tiziano Gaiotto, Walter Ramage, Christina Ball, Paul Risley, George W. Carnell, Nigel Temperton, Othmar G. Engelhardt, Simon E. Hufton
Published 2021-02-01

Cross-Reactive and Lineage-Specific Single Domain Antibodies against Influenza B Hemagglutinin

by Walter Ramage, Tiziano Gaiotto, Christina Ball, Paul Risley, George W. Carnell, Nigel Temperton, Chung Y. Cheung, Othmar G. Engelhardt, Simon E. Hufton
Published 2019-02-01

Protection From Influenza by Intramuscular Gene Vector Delivery of a Broadly Neutralizing Nanobody Does Not Depend on Antibody Dependent Cellular Cytotoxicity

by Joanne Marie M. Del Rosario, Joanne Marie M. Del Rosario, Joanne Marie M. Del Rosario, Joanne Marie M. Del Rosario, Matthew Smith, Kam Zaki, Paul Risley, Nigel Temperton, Othmar G. Engelhardt, Mary Collins, Mary Collins, Mary Collins, Yasuhiro Takeuchi, Yasuhiro Takeuchi, Simon E. Hufton
Published 2020-05-01

Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses

by Georgia Bullen, Jacob D. Galson, Gareth Hall, Pedro Villar, Lien Moreels, Line Ledsgaard, Giada Mattiuzzo, Emma M. Bentley, Edward W. Masters, David Tang, Sophie Millett, Danielle Tongue, Richard Brown, Ioannis Diamantopoulos, Kothai Parthiban, Claire Tebbutt, Rachael Leah, Krishna Chaitanya, Sandra Ergueta-Carballo, Deividas Pazeraitis, Sachin B. Surade, Omodele Ashiru, Lucia Crippa, Richard Cowan, Matthew W. Bowler, Jamie I. Campbell, Wing-Yiu Jason Lee, Mark D. Carr, David Matthews, Paul Pfeffer, Simon E. Hufton, Kovilen Sawmynaden, Jane Osbourn, John McCafferty, Aneesh Karatt-Vellatt
Published 2021-06-01