Prolonged treatment with DNMT inhibitors induces distinct effects in promoters and gene-bodies.

by Yan-Fung Wong, Lars Martin Jakt, Shin-Ichi Nishikawa
Published 2013-01-01

Circulation-Independent Differentiation Pathway from Extraembryonic Mesoderm toward Hematopoietic Stem Cells via Hemogenic Angioblasts

by Yosuke Tanaka, Veronica Sanchez, Nozomu Takata, Tomomasa Yokomizo, Yojiro Yamanaka, Hiroshi Kataoka, Philipp S. Hoppe, Timm Schroeder, Shin-Ichi Nishikawa
Published 2014-07-01

A simple and highly effective method for slow-freezing human pluripotent stem cells using dimethyl sulfoxide, hydroxyethyl starch and ethylene glycol.

by Keitaro Imaizumi, Naoki Nishishita, Marie Muramatsu, Takako Yamamoto, Chiemi Takenaka, Shin Kawamata, Kenichiro Kobayashi, Shin-Ichi Nishikawa, Teruo Akuta
Published 2014-01-01

Highly sensitive in vitro methods for detection of residual undifferentiated cells in retinal pigment epithelial cells derived from human iPS cells.

by Takuya Kuroda, Satoshi Yasuda, Shinji Kusakawa, Naoya Hirata, Yasunari Kanda, Kazuhiro Suzuki, Masayo Takahashi, Shin-Ichi Nishikawa, Shin Kawamata, Yoji Sato
Published 2012-01-01

Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells.

by Sentaro Kusuhara, Yoko Fukushima, Shigetomo Fukuhara, Lars Martin Jakt, Mitsuhiro Okada, Yuri Shimizu, Masayuki Hata, Kohji Nishida, Akira Negi, Masanori Hirashima, Naoki Mochizuki, Shin-Ichi Nishikawa, Akiyoshi Uemura
Published 2012-01-01

Ectopic cerebellar cell migration causes maldevelopment of Purkinje cells and abnormal motor behaviour in Cxcr4 null mice.

by Guo-Jen Huang, Andrew Edwards, Cheng-Yu Tsai, Yi-Shin Lee, Lei Peng, Takumi Era, Yoshio Hirabayashi, Ching-Yen Tsai, Shin-Ichi Nishikawa, Yoichiro Iwakura, Shu-Jen Chen, Jonathan Flint
Published 2014-01-01