Differential Regulation of Bilastine Affinity for Human Histamine H₁ Receptors by Lys 179 and Lys 191 via Its Binding Enthalpy and Entropy

by Hayato Akimoto, Minoru Sugihara, Shigeru Hishinuma
Published 2021-02-01

Molecular Determinants of the Kinetic Binding Properties of Antihistamines at the Histamine H₁ Receptors

by Hayato Akimoto, Yoshihiro Uesawa, Shigeru Hishinuma
Published 2021-02-01

Molecular Determinants Responsible for Sedative and Non-sedative Properties of Histamine H1–Receptor Antagonists

by Yoshihiro Uesawa, Shigeru Hishinuma, Masaru Shoji
Published 2014-01-01

The Affinity of Histamine for Gq Protein-Coupled Histamine H1-Receptors Is Predominantly Regulated by Their Internalization in Human Astrocytoma Cells

by Shigeru Hishinuma, Yuko Sato, Chizuru Akatsu, Masaru Shoji
Published 2012-01-01

Intact Cell Binding for In Vitro Prediction of Sedative and Non-sedative Histamine H1–Receptor Antagonists Based on Receptor Internalization

by Shigeru Hishinuma, Yuko Sato, Yusuke Kobayashi, Hiroshi Komazaki, Masaki Saito
Published 2008-01-01

Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (<i>S</i>)-Cetirizine by Lys191 in Human Histamine H₁ Receptors

by Shigeru Hishinuma, Yuri Tamura, Chihiro Kobayashi, Chizuru Akatsu, Masaru Shoji
Published 2018-12-01

Inhibition of Ectopic Arginine Vasopressin Production by Phenytoin in the Small Cell Lung Cancer Cell Line Lu-165

by Masaru Shoji, Takahiro Ohta, Takahiro Ohta, Mitsuo Mita, Shigeru Hishinuma, Reiko Ishii-Nozawa, Kazuhisa Takahashi
Published 2017-04-01