Illuminating the genome-wide activity of genome editors for safe and effective therapeutics

by Yong Cheng, Shengdar Q. Tsai
Published 2018-12-01

Easy-Prime: a machine learning–based prime editor design tool

by Yichao Li, Jingjing Chen, Shengdar Q. Tsai, Yong Cheng
Published 2021-08-01

Differences in X-chromosome transcriptional activity and cholesterol metabolism between placentae from swine breeds from Asian and Western origins.

by Steve R Bischoff, Shengdar Q Tsai, Nicholas E Hardison, Alison A Motsinger-Reif, Bradley A Freking, Dan J Nonneman, Gary A Rohrer, Jorge A Piedrahita
Published 2013-01-01

Nodal patterning without Lefty inhibitory feedback is functional but fragile

by Katherine W Rogers, Nathan D Lord, James A Gagnon, Andrea Pauli, Steven Zimmerman, Deniz C Aksel, Deepak Reyon, Shengdar Q Tsai, J Keith Joung, Alexander F Schier
Published 2017-12-01

Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

by Pan Gao, Qing Lyu, Amr R. Ghanam, Cicera R. Lazzarotto, Gregory A. Newby, Wei Zhang, Mihyun Choi, Orazio J. Slivano, Kevin Holden, John A. Walker, Anastasia P. Kadina, Rob J. Munroe, Christian M. Abratte, John C. Schimenti, David R. Liu, Shengdar Q. Tsai, Xiaochun Long, Joseph M. Miano
Published 2021-03-01

High levels of AAV vector integration into CRISPR-induced DNA breaks

by Killian S. Hanlon, Benjamin P. Kleinstiver, Sara P. Garcia, Mikołaj P. Zaborowski, Adrienn Volak, Stefan E. Spirig, Alissa Muller, Alexander A. Sousa, Shengdar Q. Tsai, Niclas E. Bengtsson, Camilla Lööv, Martin Ingelsson, Jeffrey S. Chamberlain, David P. Corey, Martin J. Aryee, J. Keith Joung, Xandra O. Breakefield, Casey A. Maguire, Bence György
Published 2019-09-01